We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which
reflect critical biological differences. We therefore examined the methylation profiles of 344 …

… Knox, Sean Clark-Garvey, Alan Weinberg, John Mandeli, Paul Christos, Madhu
Mazumdar, Shahin Rafii, Jonathan D. Schwartz … Knox, Helen Chen, Sean Clark-Garvey …

Background Previous phase 2 trials of neoadjuvant anti-PD-1 or anti-PD-L1 monotherapy in
patients with early-stage non-small-cell lung cancer have reported major pathological …

Purpose: To assess the efficacy of a single infusion of radiolabeled anti-prostate-specific
membrane antigen (PSMA) monoclonal antibody J591 (lutetium-177; 177 Lu) by prostate-…

Late infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive, neurodegenerative
lysosomal storage disease affecting the CNS and is fatal by age 8 to 12 years. A total …

Purpose Treatment of mantle-cell lymphoma (MCL) is nonstandardized, though patients are
commonly treated immediately at diagnosis. Because data on observation, or “watch and …

The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies
depends, at least in part, on the assumption that metastatic tumors are primarily clonal with …

… Paul Christos was partially supported by the following grant: Clinical Translational Science
Center (CTSC) (UL1-RR024996). The authors have no other funding, financial relationships, …

BACKGROUND Despite the importance of early detection in preventing mortality from
melanoma, little is known regarding how patients with the disease come to diagnosis. METHODS …

Background Skin-sparing mastectomy (SSM), which involves the resection of the nipple/areolar
complex with the breast parenchyma, improves the aesthetic outcome for breast cancer …