User profiles for Patrick Tan
Patrick TanDuke-NUS Medical School Verified email at duke-nus.edu.sg Cited by 37507 |
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …
aim to establish clinically relevant molecular subtypes that would encompass this …
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes
to the epigenetic silencing of target genes and regulates the survival and metastasis of …
to the epigenetic silencing of target genes and regulates the survival and metastasis of …
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …
Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia
Background Between February and April, 1999, an outbreak of viral encephalitis occurred
among pig-farmers in Malaysia. We report findings for the first three patients who died. …
among pig-farmers in Malaysia. We report findings for the first three patients who died. …
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
PS Linsley, JL Greene, P Tan, J Bradshaw… - The Journal of …, 1992 - rupress.org
T cell costimulation by molecules on the antigen presenting cell (APC) is required for
optimal T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28, …
optimal T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28, …
[HTML][HTML] Clinical features of Nipah virus encephalitis among pig farmers in Malaysia
KJ Goh, CT Tan, NK Chew, PSK Tan… - … England Journal of …, 2000 - Mass Medical Soc
Background Between September 1998 and June 1999, there was an outbreak of severe viral
encephalitis due to Nipah virus, a newly discovered paramyxovirus, in Malaysia. Methods …
encephalitis due to Nipah virus, a newly discovered paramyxovirus, in Malaysia. Methods …
Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma
…, V Rajasegaran, S Lie, AST Lim, TH Lim, J Tan… - Cancer discovery, 2017 - AACR
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries
with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining …
with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining …
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …
are emerging as treatment options. This study sought to identify the most prevalent …
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of
somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas …
somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas …
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven
malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor …
malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor …