User profiles for Patrick Tan

Patrick Tan

Duke-NUS Medical School
Verified email at duke-nus.edu.sg
Cited by 37507

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

…, JM Bae, ST Kim, SH Park, I Sohn, SH Jung, P Tan… - Nature medicine, 2015 - nature.com
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

…, JC Brenner, J Yu, JH Kim, B Han, P Tan… - science, 2008 - science.org
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes
to the epigenetic silencing of target genes and regulates the survival and metastasis of …

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

J Tan, X Yang, L Zhuang, X Jiang, W Chen… - Genes & …, 2007 - genesdev.cshlp.org
Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …

Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia

…, KJ Goh, KT Wong, A Kamarulzaman, PSK Tan… - The Lancet, 1999 - thelancet.com
Background Between February and April, 1999, an outbreak of viral encephalitis occurred
among pig-farmers in Malaysia. We report findings for the first three patients who died. …

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

PS Linsley, JL Greene, P Tan, J Bradshaw… - The Journal of …, 1992 - rupress.org
T cell costimulation by molecules on the antigen presenting cell (APC) is required for
optimal T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28, …

[HTML][HTML] Clinical features of Nipah virus encephalitis among pig farmers in Malaysia

KJ Goh, CT Tan, NK Chew, PSK Tan… - … England Journal of …, 2000 - Mass Medical Soc
Background Between September 1998 and June 1999, there was an outbreak of severe viral
encephalitis due to Nipah virus, a newly discovered paramyxovirus, in Malaysia. Methods …

Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma

…, V Rajasegaran, S Lie, AST Lim, TH Lim, J Tan… - Cancer discovery, 2017 - AACR
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries
with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining …

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …

N Deng, LK Goh, H Wang, K Das, J Tao, IB Tan… - Gut, 2012 - gut.bmj.com
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

…, A Gan, KH Lim, CK Ong, DC Huang, SY Chin, IB Tan… - Nature …, 2012 - nature.com
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of
somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas …

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

…, H Than, LC Lim, YT Goh, S Zhang, D Poh, P Tan… - Nature medicine, 2012 - nature.com
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven
malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor …