User profiles for Patricia Edem

Patricia Edem

BC Cancer
Verified email at bccancer.bc.ca
Cited by 482

[HTML][HTML] Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines

EJL Stéen, PE Edem, K Nørregaard, JT Jørgensen… - Biomaterials, 2018 - Elsevier
Pretargeted nuclear imaging and radiotherapy have recently attracted increasing attention
for diagnosis and treatment of cancer with nanomedicines. This is because it conceptually …

Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

…, UM Battisti, K Nørregaard, PE Edem… - ACS pharmacology & …, 2021 - ACS Publications
The development of highly selective and fast biocompatible reactions for ligation and cleavage
has paved the way for new diagnostic and therapeutic applications of pretargeted in vivo …

Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

…, B Sohr, D Svatunek, A Birke, V Shalgunov, PE Edem… - ACS …, 2019 - ACS Publications
Tumor targeting using agents with slow pharmacokinetics represents a major challenge in
nuclear imaging and targeted radionuclide therapy as they most often result in low imaging …

[HTML][HTML] In vivo radionuclide generators for diagnostics and therapy

PE Edem, J Fonslet, A Kjær, M Herth… - Bioinorganic Chemistry …, 2016 - hindawi.com
In vivo radionuclide generators make complex combinations of physical and chemical
properties available for medical diagnostics and therapy. Perhaps the best-known in vivo …

[HTML][HTML] Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

PE Edem, JP Sinnes, S Pektor, N Bausbacher… - EJNMMI research, 2019 - Springer
Background Pretargeted imaging allows the use of short-lived radionuclides when imaging
the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)…

[HTML][HTML] Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging

PE Edem, JT Jørgensen, K Nørregaard, R Rossin… - Molecules, 2020 - mdpi.com
The bioorthogonal reaction between a tetrazine and strained trans-cyclooctene (TCO) has
garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging …

[HTML][HTML] Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C] AE-1 for pretargeted PET imaging

…, S Lehel, V Shalgunov, A Birke, PE Edem… - Bioorganic & Medicinal …, 2019 - Elsevier
Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting
agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve …

Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B

PE Edem, S Czorny, JF Valliant - Journal of Medicinal Chemistry, 2014 - ACS Publications
Dipeptidyl (acyloxy)methyl ketones (AOMKs) were functionalized with different iodine-containing
prosthetic groups to generate a library of candidate cathepsin B probes. Compound 23a…

Imidazole fused phenanthroline (PIP) ligands for the preparation of multimodal re (I) and 99m Tc (I) probes

…, L Banevicius, N Mercanti, PE Edem… - Dalton …, 2020 - pubs.rsc.org
A small library of [2 + 1] 99mTc(I) complexes based on phenyl-imidazole-fused phenanthroline
(PIP) ligands were synthesized and evaluated as multimodal molecular imaging probes. …

[HTML][HTML] Quantitative evaluation of PSMA PET imaging using a realistic anthropomorphic phantom and shell-less radioactive epoxy lesions

R Fedrigo, DJ Kadrmas, PE Edem, L Fougner… - EJNMMI physics, 2022 - Springer
Background Positron emission tomography (PET) with prostate specific membrane antigen (PSMA)
have shown superior performance in detecting metastatic prostate cancers. Relative …