Clinical trials of new cancer drugs should ideally include measurements of parameters such
as molecular target expression, pharmacokinetic (PK) behavior, and pharmacodynamic (PD…

3′-Deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT) has been proposed as a new marker for
imaging tumor proliferation by positron emission tomography (PET). The uptake of [ 18 F]FLT …

With most of the T cells residing in the tissue, not the blood, developing noninvasive methods
for in vivo quantification of their biodistribution and kinetics is important for studying their …

Purpose The aim of this study was to investigate the role of thymidine kinase 1 (TK 1 )
protein in 3′-deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT) positron emission tomography (PET) …

Background Fluorouracil is widely used for chemotherapy of gastrointestinal cancer, but
response rates are poor. Eniluracil is being developed as an inactivator of dihydropyrimidine …

Background: Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for
thymidine nucleotide biosynthesis. Cells can compensate for depleted thymidine levels by …

PURPOSE: To evaluate tumor, normal tissue, and plasma pharmacokinetics of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
(DACA). The study aimed to determine the …

Positron emission tomography (PET) provides the oncologist with information on tumour
diagnosis, and treatment response monitoring. Mathematical modelling of tissue data, and …

2-[ 11 C ]Thymidine has been produced from [ 11 C ]methane via [ 11 C ]phosgene and [ 11
C ]urea. Anhydrous [ 11 C ]urea was prepared from [ 11 C ]phosgene by reaction with liquid …

Purpose: Pharmacokinetic parameters derived from plasma sampling are used as a surrogate
of tumor pharmacokinetics. However, pharmacokinetics-modulating strategies do not …