Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by
a combination of environmental and genetic factors, which include variation in MHC genes …

Type 1 diabetes is caused by the immune-mediated destruction of islet insulin-secreting β-cells.
This chronic destructive process is associated with both cellular and humoral immune …

The underlying cause of type 1 diabetes, loss of β-cell function, has become the therapeutic
target for a number of interventions in patients with type 1 diabetes. Even though insulin …

Context: The aim of this review was to explore the pathogenic and clinical spectrum of type
1 diabetes, which includes a form of adult onset autoimmune diabetes usually referred to as …

… Paolo Pozzilli, Alberto Signore, Alistair JK Williams and … Here Paolo Pozzilli and colleagues
comment on the results of … 323-334 3 Signore, A., Pozzilli, P., Gale, E..a .M., Andreani, r~ ~n,4 …

Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood
glucose, is among the most common chronic diseases. The incidence and prevalence of …

Aims/hypothesis The aim of this study was to investigate the evidence of an increased risk
of childhood-onset type 1 diabetes in children born by Caesarean section by systematically …

Previous studies have suggested more than 20 genetic intervals that are associated with
susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been …

Background In most patients with type 1 diabetes, adequate glycemic control is not achieved
with insulin therapy alone. We evaluated the safety and efficacy of sotagliflozin, an oral …

Background Hypovitaminosis D has been recently recognized as a worldwide epidemic.
Since vitamin D exerts significant metabolic activities, comprising free fatty acids (FFA) flux …