Objective: Activated microglia are thought to play a major role in cortical gray matter (GM)
demyelination in multiple sclerosis (MS). Our objective was to evaluate microglial activation in …

Background Depression, a condition commonly comorbid with multiple sclerosis (MS), is
associated more generally with elevated inflammatory markers and hippocampal pathology. …

Previous studies have shown activation of the immune system and altered immune response
in Huntington's disease (HD) gene carriers. Here, we hypothesized that peripheral and …

PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients
with multiple sclerosis (MS) primarily reflects activated microglia and macrophages. We …

The most accurate predictor of the subsequent development of multiple sclerosis in clinically
isolated syndrome is the presence of lesions at magnetic resonance imaging. We used in …

The pathophysiological correlates and the contribution to persisting disability of hypointense
T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In …

The emergence of oral disease-modifying therapies in multiple sclerosis (MS) will have a
significant impact on the evolving scenario of immunomodulatory treatments in MS where …

Multiple sclerosis (MS) arises from an immune attack on the central nervous system producing
demyelination and axonal loss. Clinically the relapsing–remitting course is characterized …

OBJECTIVE: To investigate in vivo whether one-year treatment with natalizumab can influence
levels of activated microglia in brain areas which were found to be related to disability in …

Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular
and molecular mechanisms by which Btk mediates inflammation are poorly understood. Here …