Stem cell factor (SCF) and its receptor c-kit take part in the regulation of developmental
processes of mast cells, hematopoietic stem cells, and melanocytes, as well as in the growth …

Sixty-eight patients with inflammatory breast carcinoma (IBC) received treatment in 2
prospective randomized trials of multimodality therapy for locally advanced breast cancer. The …

Congenital hypothyroidism due to impaired thyroid response to TSH was originally described
by Stanbury. A diagnosis of congenital hypothyroidism with thyroid unresponsiveness to …

Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal
and pathological cellular events including tumour invasion and metastasis. Cells bind laminin …

Background: Available prognostic factors do not accurately identify node-negative breast
cancer patients at high risk of disease recurrence and progression. Patients and Methods: …

Two human NM23 genes have been identified: NM23.HI and NM23.H2 coding for the A and
B subunit of a nucleoside diphosphate kinase (NDPK), respectively. NM23.HI gene has …

The phosphoinositide 3-kinase/Akt pathway is involved in the pathogenesis of several
human cancers. In this study, the biological and prognostic value of phosphoinositide 3-kinase/Akt …

Von Hipple–Lindau gene (VHL) inactivation represents the most frequent abnormality in
clear cell renal cell carcinoma (ccRCC). Hypoxia-inducible factor-1α (HIF-1α) expression is …

Objectives The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-RCC)
is inactivation of Von Hippel-Lindau gene (VHL). pVHL19 is a ligase promoting …

BRMS1 is regarded as a metastasis suppressor gene for its ability to reduce metastatic
potential of human and murine breast cancer cells as well as human melanoma cells. However, …