Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor
…, N Harada, Y Nakamura, M Noguchi, P Leland… - Science, 1993 - science.org
The interleukin-2 (IL-2) receptor γ chain (IL-2Rγ) is an essential component of high- and
intermediate-affinity IL-2 receptors. IL-2Rγ was demonstrated to be a component of the IL-4 …
intermediate-affinity IL-2 receptors. IL-2Rγ was demonstrated to be a component of the IL-4 …
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
…, M Prados, D Croteau, C Pedain, P Leland… - Neuro …, 2010 - academic.oup.com
Convection-enhanced delivery (CED) of cintredekin besudotox (CB) was compared with
Gliadel wafers (GW) in adult patients with glioblastoma multiforme (GBM) at first recurrence. …
Gliadel wafers (GW) in adult patients with glioblastoma multiforme (GBM) at first recurrence. …
Targeting of IL-4 and IL-13 receptors for cancer therapy
The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They
regulate immune responses and the immune microenvironment, not only under normal …
regulate immune responses and the immune microenvironment, not only under normal …
In Situ Expression of Interleukin-4 (IL-4) Receptors in Human Brain Tumors and Cytotoxicity of a Recombinant IL-4 Cytotoxin in Primary Glioblastoma …
BH Joshi, P Leland, A Asher, RA Prayson, F Varricchio… - Cancer Research, 2001 - AACR
We have reported that human malignant glioma cell lines express high levels of plasma
membrane interleukin-4 receptors (IL-4R). We have also reported that biopsy/surgical samples …
membrane interleukin-4 receptors (IL-4R). We have also reported that biopsy/surgical samples …
IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis
…, A Schirbel, M Scarpa, G West, C Yi, L Xu, P Leland… - Gut, 2014 - gut.bmj.com
Objective Previous studies have shown that ulcerative colitis (UC) is associated with the
presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating …
presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating …
Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of …
RK Puri, P Leland, NI Obiri, SR Husain, RJ Kreitman… - 1996 - ashpublications.org
We have previously shown that human renal cell carcinoma (RCC) cells express large
numbers of interleukin-13 receptors (IL-13R), a newly described hemopoietic growth factor …
numbers of interleukin-13 receptors (IL-13R), a newly described hemopoietic growth factor …
Human neurological cancer cells express interleukin‐4 (IL‐4) receptors which are targets for the toxic effects of IL4‐pseudomonas exotoxin chimeric protein
RK Puri, P Leland, RJ Kreitman… - International journal of …, 1994 - Wiley Online Library
Glioblastoma, glioma or neuroblastoma cells were examined for the expression of IL‐4
receptors (IL‐4R) by flow cytometric analysis and 125 I‐IL‐4 binding. These cancer cell lines …
receptors (IL‐4R) by flow cytometric analysis and 125 I‐IL‐4 binding. These cancer cell lines …
Preclinical Development of a Recombinant Toxin Containing Circularly Permuted Interleukin 4 and Truncated Pseudomonas Exotoxin for Therapy of Malignant …
RK Puri, DS Hoon, P Leland, P Snoy, RW Rand… - Cancer research, 1996 - AACR
Effective treatment is lacking for malignant glioblastoma/astrocytoma. We have identified
interleukin-4 receptors (IL-4R) on human malignant astrocytoma. We demonstrate that 16 of 21 …
interleukin-4 receptors (IL-4R) on human malignant astrocytoma. We demonstrate that 16 of 21 …
In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line.
MR Hollingdale, P Leland… - The American journal of …, 1983 - europepmc.org
When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16)
derived from human liver supports the complete asexual developmental cycle of the …
derived from human liver supports the complete asexual developmental cycle of the …
Interleukin‐4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease
BH Joshi, P Leland, S Lababidi, F Varrichio… - Cancer …, 2014 - Wiley Online Library
Previously, we have demonstrated that interleukin‐4 receptor α ( IL ‐4Rα) is overexpressed
on a variety of human cancers and can serve as target for IL ‐4 immunotoxin comprised of IL …
on a variety of human cancers and can serve as target for IL ‐4 immunotoxin comprised of IL …