User profiles for Pablo Bascuñana
Pablo Bascuñana (ORCID 0000-0003-2186-8899)Departamento de Medicina Nuclear, Hospital Clínico San Carlos, IdISSC, Madrid Verified email at ucm.es Cited by 666 |
The insulin‐like growth factor I receptor regulates glucose transport by astrocytes
Previous findings indicate that reducing brain insulin‐like growth factor I receptor (IGF‐IR)
activity promotes ample neuroprotection. We now examined a possible action of IGF‐IR on …
activity promotes ample neuroprotection. We now examined a possible action of IGF‐IR on …
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy
…, C Brandt, M Bankstahl, P Bascuñana… - Annals of …, 2016 - Wiley Online Library
Objective Acquired epilepsy is a devastating long‐term risk of various brain insults, including
trauma, stroke, infections, and status epilepticus (SE). There is no preventive treatment for …
trauma, stroke, infections, and status epilepticus (SE). There is no preventive treatment for …
Serial quantitative TSPO-targeted PET reveals peak microglial activation up to 2 weeks after an epileptogenic brain insult
M Brackhan, P Bascuñana, JM Postema… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Experimental and clinical evidence suggests that neuroinflammation, triggered by
epileptogenic insults, contributes to seizure development. We used translocator protein–targeted …
epileptogenic insults, contributes to seizure development. We used translocator protein–targeted …
[HTML][HTML] Fingolimod as a treatment in neurologic disorders beyond multiple sclerosis
Fingolimod is an approved treatment for relapsing–remitting multiple sclerosis (MS), and its
properties in different pathways have raised interest in therapy research for other …
properties in different pathways have raised interest in therapy research for other …
Blood–brain barrier leakage during early epileptogenesis is associated with rapid remodeling of the neurovascular unit
M Bankstahl, H Breuer, I Leiter, M Märkel, P Bascuñana… - Eneuro, 2018 - eneuro.org
Increased permeability of the blood–brain barrier (BBB) following cerebral injury results in
regional extravasation of plasma proteins and can critically contribute to the pathogenesis of …
regional extravasation of plasma proteins and can critically contribute to the pathogenesis of …
[HTML][HTML] ABC transporter C1 prevents dimethyl fumarate from targeting Alzheimer's disease
Simple Summary Reusing drugs could potentially shorten the development time for the
effective treatment of dementia. Here, we tested a drug—dimethyl fumarate—for its efficacy in …
effective treatment of dementia. Here, we tested a drug—dimethyl fumarate—for its efficacy in …
[HTML][HTML] Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia
N Hermanns, V Wroblewski, P Bascuñana… - Basic Research in …, 2022 - Springer
Ischemic stroke imparts elevated risk of heart failure though the underlying mechanisms
remain poorly described. We aimed to characterize the influence of cerebral ischemic injury on …
remain poorly described. We aimed to characterize the influence of cerebral ischemic injury on …
[HTML][HTML] Time-and sex-dependent effects of fingolimod treatment in a mouse model of alzheimer's disease
P Bascuñana, M Brackhan, L Möhle, J Wu, T Brüning… - Biomolecules, 2023 - mdpi.com
Alzheimer’s disease (AD) is the most common cause of dementia. Fingolimod has
previously shown beneficial effects in different animal models of AD. However, it has shown …
previously shown beneficial effects in different animal models of AD. However, it has shown …
[HTML][HTML] Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice
Introduction Alzheimer’s disease (AD) is the leading cause of dementia and a major global
health issue. Currently, only limited treatment options are available to patients. One …
health issue. Currently, only limited treatment options are available to patients. One …
[HTML][HTML] Development of deep learning models for microglia analyses in brain tissue using DeePathology™ STUDIO
L Möhle, P Bascunana, M Brackhan… - Journal of neuroscience …, 2021 - Elsevier
Background Interest in artificial intelligence-driven analysis of medical images has seen a
steep increase in recent years. Thus, our paper aims to promote and facilitate the use of this …
steep increase in recent years. Thus, our paper aims to promote and facilitate the use of this …