Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

…, VJ Lotti, DJ Cerino, TB Chen, PJ Kling… - Journal of medicinal …, 1988 - ACS Publications
3-(Acylamino)-5-phenyl-2H-l, 4-benzodiazepines, antagonists of the peptide hormone
cholecystokinin (CCK), are described. Developed by reasoned modificationof the known …

Thrombocytopenia and platelet transfusion in the neonate

M Cremer, H Sallmon, PJ Kling, C Bührer… - Seminars in Fetal and …, 2016 - Elsevier
Neonatal thrombocytopenia is widespread in preterm and term neonates admitted to neonatal
intensive care units, with up to one-third of infants demonstrating platelet counts <150 × …

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic …

…, RM Freidinger, RW Ransom, P Kling… - Journal of medicinal …, 2000 - ACS Publications
α 1 Adrenergic receptors mediate both vascular and lower urinary tract tone, and α 1
receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign …

Mechanisms of heavy metal accumulation and toxicity in fish

PE Olsson, P Kling, C Hogstrand - Metal metabolism in aquatic …, 1998 - Springer
As a result of mining, forestry, waste disposal and fuel combustion, our environment is becoming
increasingly contaminated with heavy metals. The aquatic environment receives waste …

Leptin and leptin receptor genes in Atlantic salmon: cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status

…, AGG Moen, SO Stefansson, P Kling… - General and …, 2010 - Elsevier
The present study reports the complete coding sequences for two paralogues for leptin (sLepA1
and sLepA2) and leptin receptor (sLepR) in Atlantic salmon. The deduced 171-amino …

Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones

…, TW Schorn, TB Chen, S O'Malley, P Kling… - Journal of medicinal …, 1999 - ACS Publications
Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype
selectivity for the cloned human α 1a receptor. Systematic modifications of 12 led to …

The impact of temperature on the metabolome and endocrine metabolic signals in Atlantic salmon (Salmo salar)

…, K Sundell, L Samuelsson, K Wiklander, P Kling… - … and Physiology Part A …, 2013 - Elsevier
… CF was affected by temperature and time (P = 0.02 and P < 0.0001, respectively), with a
significant interaction between these variables (P < 0.0001). The fish at 18 C had higher CF than …

A homologous salmonid leptin radioimmunoassay indicates elevated plasma leptin levels during fasting of rainbow trout

P Kling, I Rønnestad, SO Stefansson… - General and …, 2009 - Elsevier
… In all statistical tests, differences were accepted as statistically different at the level of p <
0.05. … The RCN-financing of a postdoctoral position for P. Kling is especially acknowledged. …

Anemia in children after transplantation: etiology and the effect of immunosuppressive therapy on erythropoiesis

A Al‐Uzri, PD Yorgin, PJ Kling - Pediatric transplantation, 2003 - Wiley Online Library
Anemia in children after renal transplantation is more common than previously appreciated.
Multiple factors appear to play roles in the development of post‐transplant anemia, the most …

Plasma leptin and growth hormone levels in the fine flounder (Paralichthys adspersus) increase gradually during fasting and decline rapidly after refeeding

EN Fuentes, P Kling, IE Einarsdottir, M Alvarez… - General and …, 2012 - Elsevier
In fish, recent studies have indicated an anorexigenic role of leptin and thus its possible
involvement in regulation of energy balance and growth. In the present study, the effects of …