User profiles for P. J. Kenny

Kenny PJ

Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Cited by 19937

[PDF][PDF] Reward mechanisms in obesity: new insights and future directions

PJ Kenny - Neuron, 2011 - cell.com
Food is consumed in order to maintain energy balance at homeostatic levels. In addition,
palatable food is also consumed for its hedonic properties independent of energy status. Such …

Neurobiological mechanisms in the transition from drug use to drug dependence

…, SH Ahmed, B Boutrel, SA Chen, PJ Kenny… - Neuroscience & …, 2004 - Elsevier
Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss
of control over intake, and impairment in social and occupational function. Animal models …

Common cellular and molecular mechanisms in obesity and drug addiction

PJ Kenny - Nature Reviews Neuroscience, 2011 - nature.com
The hedonic properties of food can stimulate feeding behaviour even when energy requirements
have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of …

Front-end factor analysis for speaker verification

N Dehak, PJ Kenny, R Dehak… - … on Audio, Speech …, 2010 - ieeexplore.ieee.org
This paper presents an extension of our previous work which proposes a new speaker
representation for speaker verification. In this modeling, a new low-dimensional speaker- and …

Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

PM Johnson, PJ Kenny - Nature neuroscience, 2010 - nature.com
We found that development of obesity was coupled with emergence of a progressively worsening
deficit in neural reward responses. Similar changes in reward homeostasis induced by …

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

…, TE Morgan, CE Finch, G St. Laurent III, PJ Kenny… - Nature medicine, 2008 - nature.com
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Negative feedback control of neuronal activity by microglia

…, WG Junger, R Sebra, ES Calipari, PJ Kenny… - Nature, 2020 - nature.com
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying
neurons, pruning non-functional synapses, and producing ligands that support neuronal …

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

CD Fowler, Q Lu, PM Johnson, MJ Marks, PJ Kenny - Nature, 2011 - nature.com
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

B Boutrel, PJ Kenny, SE Specio… - Proceedings of the …, 2005 - National Acad Sciences
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides
synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-…

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

HI Im, JA Hollander, P Bali, PJ Kenny - Nature neuroscience, 2010 - nature.com
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …