User profiles for P. J. Kenny
Kenny PJIcahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 19937 |
[PDF][PDF] Reward mechanisms in obesity: new insights and future directions
PJ Kenny - Neuron, 2011 - cell.com
Food is consumed in order to maintain energy balance at homeostatic levels. In addition,
palatable food is also consumed for its hedonic properties independent of energy status. Such …
palatable food is also consumed for its hedonic properties independent of energy status. Such …
Neurobiological mechanisms in the transition from drug use to drug dependence
Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss
of control over intake, and impairment in social and occupational function. Animal models …
of control over intake, and impairment in social and occupational function. Animal models …
Common cellular and molecular mechanisms in obesity and drug addiction
PJ Kenny - Nature Reviews Neuroscience, 2011 - nature.com
The hedonic properties of food can stimulate feeding behaviour even when energy requirements
have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of …
have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of …
Front-end factor analysis for speaker verification
This paper presents an extension of our previous work which proposes a new speaker
representation for speaker verification. In this modeling, a new low-dimensional speaker- and …
representation for speaker verification. In this modeling, a new low-dimensional speaker- and …
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
PM Johnson, PJ Kenny - Nature neuroscience, 2010 - nature.com
We found that development of obesity was coupled with emergence of a progressively worsening
deficit in neural reward responses. Similar changes in reward homeostasis induced by …
deficit in neural reward responses. Similar changes in reward homeostasis induced by …
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
…, TE Morgan, CE Finch, G St. Laurent III, PJ Kenny… - Nature medicine, 2008 - nature.com
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …
Negative feedback control of neuronal activity by microglia
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying
neurons, pruning non-functional synapses, and producing ligands that support neuronal …
neurons, pruning non-functional synapses, and producing ligands that support neuronal …
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides
synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-…
synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-…
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …