Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but
its causal role remains controversial. We used a Mendelian randomization approach to test …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic
blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide association …

… Patients involved in errors were more likely to be older (P<.0001) and more likely to have
higher visit level intensity (P<.0001) than registered ED patients. Ninety-eight percent of errors …

Purpose of Review The metabolic syndrome is a pathological state in which one of the key
components is insulin resistance. A wide spectrum of body compartments is involved in its …

Cushing's syndromemay be produced by a functioning tumour of the adrenal cortex but more
often it is a consequence of hyperplasia and hyperfunction of the adrenal cortices in the …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

… leptin levels from 32,161 individuals and followed up loci reaching P<10 −6 in 19,979
additional individuals. We identify five loci robustly associated (P<5 × 10 −8 ) with leptin levels in/…