Oncogenic activation of the proto-oncogene c- abl in human leukemias occurs as a result of
the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of …

We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which
is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1, SH2…

The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial
for B cell development. Loss of kinase activity results in the human immunodeficiency, X-…

The va &l protein is known to be a tyrosine-specific protein kinase. However, its normal cellular
homolog, c-ah/P150, is not detectably phosphorylated on tyrosine in vivo or in vitro. The …

The identification of cell surface antigens is critical to the development of new diagnostic and
therapeutic modalities for the management of prostate cancer. Prostate stem cell antigen (…

Chronic myelogenous leukemia (CML) is a human disease associated with a consistent
chromosomal translocation that results in sequences from the c-abl locus on chromosome 9 …

Growth of mature B cells and their precursors from mouse bone marrow was maintained in
culture for greater than 1 year. Feeder layers of adherent bone marrow cells, established in …

Background: Recombinant human bone morphogenetic proteins (rhBMPs) can induce bone
formation, but the inability to identify an ideal delivery system limits their clinical application. …

Luminal cells are believed to be the cells of origin for human prostate cancer, because the
disease is characterized by luminal cell expansion and the absence of basal cells. Yet …

The myc family of cellular oncogenes contains three known members. The N-myc and c-myc
genes have 5′-noncoding exons, strikingly homologous coding regions 1–3 , and display …