The worldwide proliferation of persistent environmental pollutants is accelerating at an alarming
rate. Not surprisingly, many of these pollutants pose a risk to human health. In this review…

Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels–Alder
reaction has shown promise in murine models of disease, yet the radiation dosimetry of this …

Despite decades of work, small-cell lung cancer (SCLC) remains a frustratingly recalcitrant
disease. Both diagnosis and treatment are challenges: low-dose computed tomography (the …

Radiolabeled antibodies have become indispensable tools in nuclear medicine. However,
the natural roles of antibodies within the immune system mean that they have several intrinsic …

Radiolabeled antibodies have shown promise as tools for both the nuclear imaging and
endoradiotherapy of cancer, but the protracted circulation time of radioimmunoconjugates can …

Radioimmunotherapy (RIT) has long stood as a promising approach to radiopharmaceutical
therapy (RPT). However, the relatively slow pharmacokinetic profile of full-length …

The N-linked biantennary glycans on the heavy chain of immunoglobulin G (IgG) antibodies
(mAbs) are instrumental in the recognition of the Fc region by Fc-gamma receptors (FcγR). …

Background Pretargeting-based approaches are being investigated for radioimmunoimaging
and therapy applications to reduce the effective radiation burden to the patient. To date, …

The proliferation of plastics in the environment continues at an alarming rate. Plastic particles
have been found to be persistent and ubiquitous pollutants in a variety of environments, …

Recent years have played witness to the advent of nuclear theranostics: the synergistic use
of “matched pair” radiopharmaceuticals for diagnostic imaging and targeted radiotherapy. In …