[HTML][HTML] Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia
O ElMokh, S Matsumoto, P Biniecka, A Bellotti… - Cell Death & …, 2022 - nature.com
Most cancer cells have high need for nicotinamide adenine dinucleotide (NAD + ) to sustain
their survival. This led to the development of inhibitors of nicotinamide (NAM) …
their survival. This led to the development of inhibitors of nicotinamide (NAM) …
[HTML][HTML] Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
APO866 is a small molecule drug that specifically inhibits nicotinamide phosphoribosyltransferase
(NAMPT), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) …
(NAMPT), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) …
[HTML][HTML] Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
O ElMokh, D Ruffieux-Daidié, MA Roelli, A Stooss… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Anaplastic thyroid cancers and radioiodine resistant thyroid cancer are posing a major treat
since surgery combined with Iodine 131 therapy is ineffective on them. Small-molecule …
since surgery combined with Iodine 131 therapy is ineffective on them. Small-molecule …
[HTML][HTML] PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant …
MA Roelli, D Ruffieux-Daidié, A Stooss, O ElMokh… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF V600E mutation
is found in 40% of the papillary type and 25% of the anaplastic type. BRAF V600E inhibitors …
is found in 40% of the papillary type and 25% of the anaplastic type. BRAF V600E inhibitors …
MEK inhibition induces therapeutic iodine uptake in a murine model of anaplastic thyroid cancer
O ElMokh, V Taelman, P Radojewski… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Anaplastic thyroid carcinoma (ATC) is refractory to radioiodine therapy in part because of
impaired iodine metabolism. We targeted the mitogen-activated protein kinase and …
impaired iodine metabolism. We targeted the mitogen-activated protein kinase and …
[CITATION][C] Cancer anaplasique de la thyroïde: challenges et nouvelles approches thérapeutiques
O El Mokh - 2018
[CITATION][C] Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
…, AJ Cloux, O ElMokh… - SWISS …, 2019 - EMH SWISS MEDICAL …
[CITATION][C] Dependency on the adenosine deaminase ADAR1 in cancer cells
…, AJ Cloux, O ElMokh… - SWISS …, 2019 - EMH SWISS MEDICAL …
[CITATION][C] Targeting MAPK and PI3K Pathways in Anaplastic Thyroid Carcinoma and Potential Treatments
O El Mokh - 2017 - Faculty of Medicine of the University …
[PDF][PDF] Molecular characterization of mechanisms involved in the antitumor activities of NAD biosynthesis inhibitor
S Matsumoto - 2023 - serval.unil.ch
… Oussama ElMokh, for showing me how to work in the lab when I joined the group. I thank
Sonia Schmutz for her help for all the administrative works. I wish to thank the members of the …
Sonia Schmutz for her help for all the administrative works. I wish to thank the members of the …