To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find
associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced …

Changes of neuronal excitability and γ-aminobutyric acid (GABA A )-receptor expression
were studied in the surround of photothrombotic infarcts, which were produced in the …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão’s historic discoveries of spreading depression and asphyxial/anoxic …

This study describes local immune responses in cerebral ischemia induced by permanent
occlusion of the middle cerebral artery (MCAO) in the rat. The temporal and spatial pattern of …

The contribution of the immune system to the pathogenesis of ischemic lesions is still uncertain.
We have analyzed leukocyte infiltration in photochemically induced focal ischemia of the …

Transient and permanent focal cerebral ischemia results in a series of typical pathophysiologic
events. These consequences evolve in time and space and are not limited to the lesion …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Functional recovery after stroke is partly due to cortical reorganization on a structural as well
as a functional level. Recent investigations have shown that the excitability of brain areas …

Background Investigations following stroke first of all require information about the spatio-temporal
dimension of the ischemic core as well as of perilesional and remote affected tissue. …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …