Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
…, T Ishizuka, K Hagihara, NA Farid, O Okazaki… - Drug Metabolism and …, 2010 - ASPET
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms
involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically …
involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically …
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy
…, KS Chung, A Hasegawa, R Nagai, O Okazaki… - Nature …, 1997 - nature.com
Hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in the young,
is an autosomal dominant disease characterized by ventricular hypertrophy accompanied …
is an autosomal dominant disease characterized by ventricular hypertrophy accompanied …
Nighttime blood pressure phenotype and cardiovascular prognosis: practitioner-based nationwide JAMP study
…, T Yoshida, H Abe, T Katsuya, Y Fujita, O Okazaki… - Circulation, 2020 - Am Heart Assoc
Background: Ambulatory and home blood pressure (BP) monitoring parameters are better
predictors of cardiovascular events than are office BP monitoring parameters, but there is a …
predictors of cardiovascular events than are office BP monitoring parameters, but there is a …
A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding
…, A Kurihara, Y Nagai, D Nakai, O Okazaki - Drug Metabolism and …, 2009 - ASPET
The risk of idiosyncratic drug toxicity (IDT) is of great concern to the pharmaceutical industry.
Current hypotheses based on retrospective studies suggest that the occurrence of IDT is …
Current hypotheses based on retrospective studies suggest that the occurrence of IDT is …
[HTML][HTML] Low-dose edoxaban in very elderly patients with atrial fibrillation
…, T Yoshida, M Kawata, O Okazaki… - … England Journal of …, 2020 - Mass Medical Soc
Background Implementation of appropriate oral anticoagulant treatment for the prevention
of stroke in very elderly patients with atrial fibrillation is challenging because of concerns …
of stroke in very elderly patients with atrial fibrillation is challenging because of concerns …
Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide
…, K Masuda, H Honma, A Kurihara, O Okazaki - Drug metabolism and …, 2010 - ASPET
Acyl glucuronides (AGs) formed from carboxylic acid-containing drugs have been considered
to be a cause of idiosyncratic drug toxicity (IDT). Chemical stability of AGs is supposed to …
to be a cause of idiosyncratic drug toxicity (IDT). Chemical stability of AGs is supposed to …
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel
…, A Kurihara, M Yoshiike, K Honda, O Okazaki… - Drug metabolism and …, 2009 - ASPET
The efficiency and interindividual variability in bioactivation of prasugrel and clopidogrel
were quantitatively compared and the mechanisms involved were elucidated using 20 …
were quantitatively compared and the mechanisms involved were elucidated using 20 …
Analytical method for the determination of disaccharides derived from keratan, heparan, and dermatan sulfates in human serum and plasma by high-performance …
T Oguma, S Tomatsu, AM Montano, O Okazaki - Analytical biochemistry, 2007 - Elsevier
We established a highly sensitive liquid chromatography tandem mass spectrometry (LC–MS/MS)
method to analyze the disaccharides produced from keratan sulfate (KS), heparan …
method to analyze the disaccharides produced from keratan sulfate (KS), heparan …
[HTML][HTML] Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis
…, R Minamimoto, Y Miyata, M Okasaki, O Okazaki… - EJNMMI research, 2014 - Springer
Background F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising
modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining …
modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining …
Screening for gestational diabetes mellitus and its prevalence in Bangladesh
…, MA Rahman, MM Islam, F Sohael, O Okazaki… - Diabetes research and …, 2014 - Elsevier
Background The prevalence of gestational diabetes mellitus (GDM) has important health
complications for both mother and child and is increasing all over the world. Although …
complications for both mother and child and is increasing all over the world. Although …