High molecular weight polymers (> 20 000 Da) have been widely used as soluble drug
carriers to improve drug targeting and therapeutic efficacy. Dendritic polymers are exceptional …

Attachment of drugs to high molecular weight polymers can significantly improve both tumor
targeting and therapeutic efficacy due to the enhanced permeability and retention effect …

A novel divergent approach was developed for the synthesis of dendritic aliphatic polyester
structures using an acetal-protected anhydride derivative of 2,2-bis(hydroxymethyl)propionic …

Human epidermal growth factor receptor type 2 (HER2) is a well-established tumor biomarker
that is overexpressed in a wide variety of cancers and that serves as a molecular target for …

Introduction The development of molecular probes based on novel engineered protein
constructs is under active investigation due to the great potential of this generalizable strategy for …

Purpose In this study, we introduce a methodology for preparing 18 F-labeled Affibody
protein, specifically 18 F-Anti-HER2 dimeric Affibody (14 kDa), for in vivo imaging of HER2neu …

Inclusivity in STEM requires practices that include transforming the culture in a classroom.
This can be done not only by placing value on diversity but also by providing an engaging …

Improving the targeting of drugs to direct them to the source of the disease, a concept initially
termed the “magic bullet” in the early 1900's, continues to be an area of special interest in …

HIV-1 subtype B virus is the most prevalent subtype in Puerto Rico (PR), accounting for about
90% of infection in the island. Recently, other subtypes and circulating recombinant forms (…

Since their discovery, dendrimers have attracted widespread interest due to their unique
structural characteristics. The introduction of convergent dendrimer synthesis in 1990 opened …