SwissTargetPrediction is a web tool, on-line since 2014, that aims to predict the most
probable protein targets of small molecules. Predictions are based on the similarity principle, …

To be effective as a drug, a potent molecule must reach its target in the body in sufficient
concentration, and stay there in a bioactive form long enough for the expected biologic events to …

The drug discovery process has been deeply transformed recently by the use of computational
ligand‐based or structure‐based methods, helping the lead compounds identification …

Here we report a phase 1b clinical trial testing the impact of oncolytic virotherapy with
talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-PD-1 …

In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Most life science processes involve, at the atomic scale, recognition between two molecules.
The prediction of such interactions at the molecular level, by so-called docking software, is …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4 (CTLA-4),
anti-programmed cell death 1 (PD-1) and anti-programmed cell death 1 ligand 1 (PD-L1) …

Bioactive small molecules, such as drugs or metabolites, bind to proteins or other macro-molecular
targets to modulate their activity, which in turn results in the observed phenotypic …

Background Early reports on patients with cancer and COVID-19 have suggested a high
mortality rate compared with the general population. Patients with thoracic malignancies are …