Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral
encephalitis in western countries. Its pathogenesis remains unclear, as it affects otherwise …

The development of functional brain asymmetry during childhood is confirmed by changes
in cerebral blood flow measured at rest using dynamic single photon emission computed …

Purpose: In severe myoclonic epilepsy of infancy (SME), multiple drug‐resistant focal and
generalized seizure types occur. Lamotrigine (LTG), found effective in many generalized and …

Regional cerebral blood flow (rCBF) was studied by SPECT using 133Xe in 42 children, aged
2 days to 19 years, considered as neurologically normal. rCBF was measured on cortical …

Malignant migrating partial seizures of infancy (MMPSI) is a rare epileptic encephalopathy
of infancy that combines pharmacoresistant seizures with developmental delay 1 . We …

Purpose: Fever induced refractory epileptic encephalopathy in school age children (FIRES)
is a devastating condition initiated by prolonged perisylvian refractory status epilepticus (SE) …

Lesch–Nyhan disease (LND) is caused by deficiency of the purine salvage enzyme
hypoxanthine-guanine phosphoribosyltransferase (HPRT). Affected individuals exhibit over-…

Subcortical laminar heterotopia (SCLH), or ‘double cortex’, is a cortical dysgenesis disorder
associated with a defect in neuronal migration. Clinical manifestations are epilepsy and …

Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1
gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine …

Frontal lobe dysfunction in adults has been associated with impairments of planning abilities,
working memory, impulse control, attention and certain aspects of motor coordination. …