Radiopharmaceutical research and development is carried out by the Center for
Radiopharmaceutical Science as part of the PSI Life Science Department, the Department of Applied …

A key limitation in developing radiotherapeutic proteins is the expense of manufacturing the
drug in small batches using traditional reaction vessels. Removing limitations on the quantity …

Peptide receptors are known to be excellent targets for in vivo cancer diagnosis and therapy
and the search for peptide-based radiopharmaceuticals has experienced an important rise …

… Many thanks go to the chemist Alain Blanc and to the lab technicians Christine De Pasquale,
Stefan Imobersteg and Olga Gasser for their help and support in the laboratories at Paul …

2.1 Abstract Aim. Bombesin (BBS) receptors are potential targets for diagnosis and therapy
of breast and prostate tumors. To overcome the rapid degradation of natural BBS some …

The overexpression of Bombesin (BBS) receptors on a variety of human cancers make them
interesting targets for tumor imaging and therapy. Analogues of the neuropeptide BBS have …

Radiolabeled bombesin (BBS) analogues are promising pharmaceuticals for imaging of
cancer cells expressing gastrin-releasing peptide receptors (GRPR). However, most of the …

… The authors wish to thank Alain Blanc, Christine De Pasquale and Olga Gasser for their
technical support, Dr. Natacha Olieric for support with the CD spectroscopy and Dr. Laura Bailey …

The glucagon-like peptide-1 receptor (GLP-1R) is highly and specifically expressed on the
pancreatic β-cells. It plays an important role in glucose metabolism as well as in β-cell-…

Riboswitches are metabolite-sensing, conserved domains located in non-coding regions of
mRNA that are central to regulation of gene expression. Here we report the first three-…