User profiles for Olaf van Tellingen
 | Olaf van TellingenNetherlands Cancer Institute Verified email at nki.nl Cited by 24503 |
[HTML][HTML] Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism
…, MA van der Valk, O van Tellingen… - The Journal of …, 2007 - Am Soc Clin Investig
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that
contributes to primary metabolism of more than half of all prescribed medications. To …
contributes to primary metabolism of more than half of all prescribed medications. To …
Modulation of the blood–brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?
…, W Boogerd, I Thuis, JH Beijnen, O van Tellingen - Cancer treatment …, 2004 - Elsevier
Systemically administered chemotherapy is not very effective in the treatment of primary or
metastatic brain tumours. An important reason for this low efficacy is insufficient drug delivery …
metastatic brain tumours. An important reason for this low efficacy is insufficient drug delivery …
[HTML][HTML] Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
JJC Verhoeff, O Van Tellingen, A Claes, LJA Stalpers… - BMC cancer, 2009 - Springer
Background The relevance of angiogenesis inhibition in the treatment of glioblastoma
multiforme (GBM) should be considered in the unique context of malignant brain tumours. …
multiforme (GBM) should be considered in the unique context of malignant brain tumours. …
Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice
O Tellingen, JH Beijnen, J Verweij… - Clinical cancer …, 1999 - AACR
We have developed and validated an analytical methodology for the quantification of
docetaxel and its four major human oxidation metabolites in mouse plasma. We have used this …
docetaxel and its four major human oxidation metabolites in mouse plasma. We have used this …
Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8
Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such
as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour …
as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour …
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
…, H Spits, O Van Tellingen… - Proceedings of the …, 1997 - National Acad Sciences
The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
…, JH Beijnen, O Van Tellingen - Proceedings of the …, 1997 - National Acad Sciences
In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause
multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins …
multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins …
Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C
…, JM Lakhai, M Van Der Valk, O Van Tellingen… - Molecular cancer …, 2002 - AACR
Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of
interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics …
interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics …
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
…, J Lankelma, O vAN Tellingen… - Proceedings of the …, 1995 - National Acad Sciences
Multidrug-resistance-associated protein (MRP) is a plasma membrane glycoprotein that can
confer multidrug resistance (MDR) by lowering intracellular drug concentration. Here we …
confer multidrug resistance (MDR) by lowering intracellular drug concentration. Here we …
The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer …
…, D Pluim, G Cipriani, P Wielinga, O van Tellingen… - Cancer research, 2005 - AACR
Imatinib mesylate (signal transduction inhibitor 571, Gleevec) is a potent and selective
tyrosine kinase inhibitor, which was shown to effectively inhibit platelet-derived growth factor–…
tyrosine kinase inhibitor, which was shown to effectively inhibit platelet-derived growth factor–…