The attachment of microbial biomass on solid surfaces is a universal phenomenon that
occurs in natural and engineering systems and is responsible for various types of biofouling. …

Parkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons
and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various …

Gut-brain axis is a dynamic, complex, and bidirectional communication network between
the gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …

The aim of this work was to simulate the effect of prostate-specific membrane antigen (PSMA)–positive
total tumor volume (TTV) on the biologically effective doses (BEDs) to tumors and …

Ibrutinib (IB), a BCS class II drug suffers from limited aqueous solubility, short half-life and
extensive first-pass metabolism. In this project, we aim to recruit the desirable properties of …

The aim of this work was to investigate the effect of ligand amount, affinity and
internalization of prostate-specific membrane antigen (PSMA)-specific ligands on the activity …

Ibrutinib (IB), which is conventionally employed for leukemia exhibits poor aqueous solubility,
poor oral bioavailability and significant food effect with a 2.15-fold increment in …

Bosutinib (BOS) is a BCS class IV drug that shows low oral bioavailability and high fast-fed
variability. Various pharmaceutical formulations have been explored thus far in order to …

Dopaminergic neurons gradually deteriorate in Parkinson’s Disease (PD), which is
characterized by the intracellular accumulation of Lewy bodies that are enriched with α-synuclein …

Purpose The knowledge of the contribution of anatomical and physiological parameters to
interindividual pharmacokinetic differences could potentially be used to improve …