Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …

Consensus virtual screening models were generated and validated utilizing a set of known
human epidermal growth factor receptor-2 (HER2) inhibitors and modeled HER2 active and …

Cancer cells are characterized by self-sufficiency in the absence of growth signals, their
ability to evade apoptosis, resistance to anti-growth signals, sustained angiogenesis, …

Highlights • PDI is an important oxidase, reductase, isomerase and molecular chaperone. •
PDI expression is up-regulated in select types of cancers. • Silencing PDI results in …

Integrins are heterodimeric, transmembrane receptors that function as mechanosensors,
adhesion molecules and signal transduction platforms in a multitude of biological processes. As …

Protein disulfide isomerase (PDI), an endoplasmic reticulum chaperone protein, catalyzes
disulfide bond breakage, formation, and rearrangement. The effect of PDI inhibition on ovarian …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

The structures of a large number of HIV-1 integrase inhibitors have in common two aryl units
separated by a central linker. Frequently at least one of these aryl moieties must contain 1,2-…

We have previously reported the inhibitory activity of curcumin against human immunodeficiency
virus type one (HIV-1) integrase. In the present study, we have synthesized and tested …