Purpose Fibrotic sequelae remain the most important dose-limiting toxicity of radiation therapy
to soft tissue. Functionally, this is reflected in loss of range of motion and muscle strength …

In this paper, we present a novel optimization algorithm for assigning weapons to targets
based on desired kill probabilities. For the given weapons, targets, and desired kill probabilities…

Multiple systems have been developed for grading the adverse effects (AEs) of cancer treatment.
The National Cancer Institute Common Toxicity Criteria (CTC) system has substantially …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We …

Acute radiation damage is most prominent in tissues with rapidly proliferating cells, such as
in epithelial surfaces of the skin or alimentary tract. Symptoms develop when functional cells …

Physicians, hospitals, and other health care facilities will assume the responsibility for aiding
individuals injured by a terrorist act involving radioactive material. Scenarios have been …

Local radiation is an established therapy for human tumors. Radiation also has been shown
to alter the phenotype of target tissue, including gene products that may make tumor cells …

CD8+ CTL play important roles against malignancy in both active and passive immunotherapy.
Nonetheless, the success of antitumor CTL responses may be improved by additional …

PURPOSE: To present nomograms providing estimates of prostate-specific antigen (PSA)
failure–free survival after radical prostatectomy (RP) or external-beam radiation therapy (RT) …

Purpose: Many patients with clinically localized prostate cancer develop biochemical failure
despite excellent local therapy perhaps due to occult metastatic disease. One potential …