[HTML][HTML] p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin iiinduced hypertrophy in vascular …

M Ushio-Fukai, AM Zafari, T Fukui, N Ishizaka… - Journal of Biological …, 1996 - ASBMB
Superoxide anion formation is vital to the microbicidal activity of phagocytes. Recently, however,
there is accumulating evidence that it is also involved in cell growth in vascular smooth …

The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD

…, H Takahashi, H Goto, S Matsui, N Ishizaka… - Modern …, 2021 - academic.oup.com
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in
Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (…

Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase

GW De Keulenaer, DC Chappell, N Ishizaka… - Circulation …, 1998 - Am Heart Assoc
Atherosclerotic lesions are found opposite vascular flow dividers at sites of low shear stress
and oscillatory flow. Since endothelial proinflammatory genes prominent in lesions are …

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats

T Fukui, N Ishizaka, S Rajagopalan… - Circulation …, 1997 - Am Heart Assoc
Recent studies suggest that superoxide production by the NADPH/NADH oxidase may be
involved in smooth muscle cell growth and the pathogenesis of hypertension. We previously …

Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals

N Ishizaka, Y Ishizaka, EI Toda, R Nagai… - … , and vascular biology, 2005 - Am Heart Assoc
Objective— There are few data available on possible independent association between uric
acid and carotid atherosclerosis. Here we first sought to investigate association between …

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

…, RW Alexander, M Ushio-Fukai, N Ishizaka… - Biochemical …, 1998 - portlandpress.com
Increasing experimental evidence suggests that non-phagocytic cells express a potent
superoxide (O 2 -• )-producing NADH oxidase that might be related to the phagocytic NADPH …

Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening

N Ishizaka, Y Ishizaka, E Takahashi, E Tooda… - The Lancet, 2002 - thelancet.com
We investigated the relation between positivity for hepatitis C virus (HCV) and carotid-artery
plaque and carotid intima-media thickening by analysing cross-sectional data of individuals …

In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage

H Mitani, N Ishizaka, T Aizawa, M Ohno, S Usui… - …, 2002 - Am Heart Assoc
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses the
expression of multiple aging-associated phenotypes. This gene is predominantly expressed in …

JCS 2016 Guideline on diagnosis and treatment of cardiac sarcoidosis―Digest version―

F Terasaki, A Azuma, T Anzai, N Ishizaka… - Circulation …, 2019 - jstage.jst.go.jp
Sarcoidosis is a systemic granulomatous disease of unknown cause. Sarcoidosis involving
the heart, ie, cardiac sarcoidosis, affects the prognosis of patients significantly as it may lead …

Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats

…, P Lou, H De Leon, JN Wilcox, N Ishizaka… - …, 1997 - Am Heart Assoc
Monocyte chemoattractant protein-1 (MCP-1), a potent monocyte chemoattractant synthesized
by vascular cells and monocytes, has been proposed to be an important mediator of …