Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior
fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further …

Background Young children with medulloblastoma have a poor overall survival compared
with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is …

Abstract Characterization of toxicity associated with cancer and its treatment is essential to
quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients, and …

PURPOSE The Children’s Oncology Group trial ACNS0121 estimated event-free survival (EFS)
and overall survival for children with intracranial ependymoma treated with surgery, …

Background Leukoencephalopathy is observed in some children undergoing chemotherapy
for acute lymphoblastic leukaemia, although its effects on long-term outcomes is unknown. …

Aims A few case series in adults have described the characteristics of epithelioid glioblastoma
( e‐GB ), one of the rarest variants of this cancer. We evaluated clinical, radiological, …

Survivors of pediatric medulloblastoma are at risk for neurocognitive dysfunction. Reduced
white matter integrity has been correlated with lower intelligence in child survivors, yet …

However, in the early years of these studies, many were limited by dependence upon self-reported
outcomes or registry data, smaller population sizes and restriction to single disease …

Purpose Long-term survivors of childhood Hodgkin lymphoma (HL) are at risk for
cardiopulmonary complications and CNS stroke, although neurocognitive function has not been …