Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N,N-dimethyltryptamine (DMT) and …

This article provides an overview of present knowledge regarding the relationship between
the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-…

Sigma receptors (subtypes sigma-1 and sigma-2) are a unique class of binding sites expressed
throughout the mammalian body. The endogenous ligand for these sites has not been …

Rationale Dopamine stabilizers have stimulatory actions under low dopamine tone and
inhibitory actions under high dopamine tone without eliciting catalepsy. These compounds are …

Tris(hydroxypyridinone) chelators conjugated to peptides can rapidly complex the positron-emitting
isotope gallium-68 ( 68 Ga) under mild conditions, and the resulting radiotracers can …

P-glycoprotein (P-gp) is an ATP-dependent efflux pump protecting the body against xenobiotics.
A P-gp substrate (7) and an inhibitor (6) were labeled with 11 C, resulting in potential …

Rationale Sigma-1 receptor agonists are under investigation as potential disease-modifying
agents for several CNS disorders. Donepezil, an acetylcholinesterase inhibitor used for the …

Background [ 18 F]BF 4 − , the first 18 F-labelled PET imaging agent for the sodium/iodide
symporter (NIS), was produced by isotopic exchange yielding a product with limited specific …

Purpose Positron emission tomography (PET) studies with radioligands for 18-kDa translocator
protein (TSPO) have been instrumental in increasing our understanding of the complex …

Purpose From a series of fluorinated analogues of puromycin, we recently identified [ 18 F]fluoroethylpuromycin
(FEPURO) as a potential candidate for imaging the rate of protein …