Breast cancer metastasis is a key determinant of long-term patient survival. By comparing
the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous …

Metastasis to bone is a major cause of morbidity in breast cancer patients, emphasizing the
importance of identifying molecular drivers of bone metastasis for new therapeutic targets. …

The cysteine cathepsins are a family of proteases that play important roles in both normal
cellular physiology and many human diseases. In cancer, the activity of many of the cysteine …

Legumain is a lysosomal cysteine protease whose biological function remains poorly defined.
Legumain activity is up-regulated in most human cancers and inflammatory diseases most …

There is a need for new molecular-guided contrast agents to enhance surgical procedures
such as tumor resection that require a high degree of precision. Cysteine cathepsins are …

Idiopathic pulmonary fibrosis (IPF) is a lethal, chronic, progressive disease characterized by
formation of scar tissue within the lungs. Because it is a disease of unknown etiology, it is …

Active enzymes, such as proteases, often serve as valuable biomarkers for various disease
pathologies. Therefore, methods to detect specific enzyme activities in biological samples …

Macrophages are cellular mediators of vascular inflammation and are involved in the
formation of atherosclerotic plaques. These immune cells secrete proteases such as matrix …

Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated
activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of …

Approximately 1-5 percent of cancer patients suffer from significant side effects in normal
tissue after radiotherapy (RT). Although RT is an effective cancer therapy, treatment dose …