The synthesis, morphology, and properties of segmented poly(ether amide)s based on flexible
PTHF segments (M n = 1.1 × 10 3 g mol –1 ) and uniform rigid oxalamide segments were …

Greater control is desirable in the stochastic conjugation technology used to synthesize
antibody–drug conjugates (ADC). We have shown recently that a fluorescent dye can be stably …

The aim of the present study was to develop folic acid (FA) conjugates which can deliver the
kinase inhibitor dactolisib to the kidneys via folate receptor-mediated uptake in tubular …

The Pt II linker [ethylenediamineplatinum(II)] 2+ , coined Lx, has emerged as a novel non‐conventional
approach to antibody–drug conjugates (ADCs) and has shown its potential in …

The potential of platinum(II) as a bifunctional linker in the coordination of small molecules,
such as imaging agents or (cytotoxic) drugs, to monoclonal antibodies (mAbs) was …

Segmented poly(ether ester amide)s comprising glycine or β-alanine extended bisoxalamide
hard segments are highly phase separated thermoplastic elastomers with a broad …

Introduction: Compared to the antibody and drug components of an ADC, the linker part has
been somewhat neglected. However, its importance for the reduction of failures in ADC …

Linker instability and impaired tumor targeting can affect the tolerability and efficacy of
antibody–drug conjugates (ADCs). To improve these ADC characteristics, we recently described …

Thermoplastic elastomers (TPEs) are known to exhibit a phase-separated morphology
which depends on their chemical structure and processing. The design of novel TPEs with …

A silver-free amination procedure, here called “complexation”, was developed to obtain a
class of Pt(II) complexes bearing a payload (such as a diagnostic or a therapeutic moiety). …