[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered
for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic …

18 F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are
implicated in neurologic disorders including Alzheimer disease and traumatic brain injury (TBI). …

Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes in diabetes,
oncology, and neurology. N‐(3‐(1H‐1,2,4‐triazol‐1‐yl)propyl)‐5‐(3‐chloro‐4‐methoxyphenyl)…

Background: Alzheimer’s disease (AD) is characterized by diffuse amyloid-β (Aβ) and
phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced 40 …

The translocator protein (TSPO) is a commonly used imaging target to investigate
neuroinflammation. Although TSPO imaging demonstrates great promise, its signal exhibits …

[ 18 F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We
examined the kinetics and longitudinal changes of extracerebral and reference regions. [ …

Purpose [ 18 F]MK6240 was developed for PET imaging of tau aggregates, which are
implicated in Alzheimer’s disease. The goal of this work was to evaluate the kinetics of [ 18 F]…

Background Mitochondrial membrane potential (ΔΨ m ) arises from normal function of the
electron transport chain. Maintenance of ΔΨ m within a narrow range is essential for …

PET is an established modality for myocardial perfusion imaging (MPI) which enables
quantification of absolute myocardial blood flow (MBF) using dynamic imaging and kinetic …

Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In
this proof-of-principle study, we investigated whether PET mapping of cardiac membrane …