Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited
expression in normal adult tissues but is highly expressed in the tumor microenvironment of …

Background Sodium–glucose linked transporter type 2 (SGLT-2) inhibition has been shown
to reduce cardiovascular mortality in heart failure independently of glycemic control and …

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Hallmarks of AD are memory impairments and cognitive deficits, but non-cognitive …

The evaluation of new therapeutic strategies in Alzheimer’s disease (AD) relies heavily on
in vivo imaging and suitable animal models that mimic the pathological changes seen in …

Spatial disorientation is one of the earliest symptoms in Alzheimer’s disease and allocentric
deficits can already be detected in the asymptomatic preclinical stages of the disease. The …

Imaging biomarkers of Alzheimer's disease (AD) that are able to detect molecular changes
in vivo and transgenic animal models mimicking AD pathologies are essential for the …

One of the hallmarks of Alzheimer’s disease (AD) are deposits of amyloid-beta (Aβ) protein
in amyloid plaques in the brain. The Aβ peptide exists in several forms, including full-length …

Aims Heart failure with preserved ejection fraction (HFpEF) is frequently (30%) associated
with right ventricular (RV) dysfunction, which increases morbidity and mortality in these …

The purpose of this prospective study was to determine the oxygen saturation of blood in the
fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses …

Chimeric inhibitors, which merge two drug pharmacophores in a single molecule have
become a prominent approach for the design of novel anticancer compounds. Here, we …