The inherent variability of symptoms and motor abnormalities in patients with the irritable
bowel syndrome has hampered the demonstration of motor abnormalities that could underlie …

Mesalamine (5-aminosalicylic acid), a topically administered anti-inflammatory agent, is
effective treatment by enema for distal ulcerative colitis; it lacks many of the side effects of orally …

The aim of this study was to assess if infusion of oleic acid into the ileal pouch would slow
gastric emptying and small-bowel transit, delay defecation, and increase plasma levels of …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a
diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …

Psychotic symptoms occur in∼ 40% of subjects with Alzheimer's disease (AD) and are
associated with more rapid cognitive decline and increased functional deficits. They show …

Popular cinema is saturated with images and narratives of empire. With" Projecting Empire",
Chapman and Cull have written the first major study of imperialism and cinema for over …

Choanoflagellates are the closest known relatives of metazoans. To discover potential
molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and …