Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with
immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which …

10.7554/eLife.03526.001 Bacterial chemotaxis systems are as diverse as the environments
that bacteria inhabit, but how much environmental variation can cells tolerate with a single …

Purpose: Because of existing controversy, the present study investigated 3 methods for
reducing surface roughness and improving the strength of porcelain restorations. Materials and …

Living cells detect and process external signals using signaling pathways that are affected
by random fluctuations. These variations cause the behavior of individual cells to fluctuate …

Cell–cell communication governs the biological behaviors of multicellular populations such
as developmental and immunological systems. Thanks to intense genetic analytical studies, …

… Nicholas Frankel approaches Wilde's writings as graphical … theoretical writings and letters,
Frankel shows that, far from … Extensive illustrations support Frankel's arguments. The first …

Biological functions are typically performed by groups of cells that express predominantly the
same genes, yet display a continuum of phenotypes. While it is known how one genotype …

Understanding how stochastic molecular fluctuations affect cell behavior requires the
quantification of both behavior and protein numbers in the same cells. Here, we combine …

Nicholas Frankel presents a revisionary account of Oscar Wilde’s final years, spent in poverty
and exile in Europe following his release from an English prison for the crime of gross …

Background: While chimeric antigen receptor (CAR) cell therapies have provided extraordinary
clinical responses in some hematological malignancies, developing effective CAR cell …