[HTML][HTML] Genomic insights into rapid speciation within the world's largest tree genus Syzygium
Species radiations, despite immense phenotypic variation, can be difficult to resolve
phylogenetically when genetic change poorly matches the rapidity of diversification. Genomic …
phylogenetically when genetic change poorly matches the rapidity of diversification. Genomic …
Preclinical development of CD38-targeted [89Zr] Zr-DFO-daratumumab for imaging multiple myeloma
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal
morbidity. Despite improvements in survival, heterogeneity in response remains a major …
morbidity. Despite improvements in survival, heterogeneity in response remains a major …
[HTML][HTML] Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI
Objective To determine the feasibility and biologic correlations of dynamic susceptibility
contrast (DSC), dynamic contrast enhanced (DCE), and quantitative maps derived from contrast …
contrast (DSC), dynamic contrast enhanced (DCE), and quantitative maps derived from contrast …
Diffusion MRI is an early biomarker of overall survival benefit in IDH wild-type recurrent glioblastoma treated with immune checkpoint inhibitors
Background Diffusion MRI estimates of the apparent diffusion coefficient (ADC) have been
shown to be useful in predicting treatment response in patients with glioblastoma (GBM), with …
shown to be useful in predicting treatment response in patients with glioblastoma (GBM), with …
[HTML][HTML] Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival
Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which is increasingly
treatable but still incurable. In 90% of MM patients, severe osteolysis results from …
treatable but still incurable. In 90% of MM patients, severe osteolysis results from …
Amine‐weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors
Amine‐weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging
(MRI) is particularly valuable as an amine‐ and pH‐sensitive imaging technique in brain …
(MRI) is particularly valuable as an amine‐ and pH‐sensitive imaging technique in brain …
The feasibility of implementing targeted sedation in mechanically ventilated emergency department patients: the ED-SED pilot trial
…, RJ Stephens, T Sewatsky, NS Cho… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: Deep sedation in the emergency department (ED) is common, increases deep
sedation in the ICU, and is negatively associated with outcome. Limiting ED deep sedation …
sedation in the ICU, and is negatively associated with outcome. Limiting ED deep sedation …
[HTML][HTML] Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas
Purpose There is limited knowledge about the associations between sodium and proton
MRI measurements in brain tumors. The purpose of this study was to quantify intra- and …
MRI measurements in brain tumors. The purpose of this study was to quantify intra- and …
[HTML][HTML] A multi-reader comparison of normal-appearing white matter normalization techniques for perfusion and diffusion MRI in brain tumors
Purpose There remains no consensus normal-appearing white matter (NAWM) normalization
method to compute normalized relative cerebral blood volume (nrCBV) and apparent …
method to compute normalized relative cerebral blood volume (nrCBV) and apparent …
[HTML][HTML] The Future Glioblastoma Clinical Trials Landscape: Early Phase 0, Window of Opportunity, and Adaptive Phase I–III Studies
NS Cho, WK Wong, PL Nghiemphu… - Current Oncology …, 2023 - Springer
Purpose of Review Innovative clinical trial designs for glioblastoma (GBM) are needed to
expedite drug discovery. Phase 0, window of opportunity, and adaptive designs have been …
expedite drug discovery. Phase 0, window of opportunity, and adaptive designs have been …