Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the identification
of translatable vulnerabilities for metabolism-targeted therapy. How molecular alterations …

Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for
new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-…

Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is
associated with therapy resistance in multiple cancer types. To gain insight into the underlying …

A first-in-class HK2 antisense oligonucleotide suppresses HK2 expression in cell culture
and in in vivo , presenting an effective, tolerated combination therapy for preventing …

Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear
cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor …

Although absent in most adult tissues, hexokinase 2 (HK2) is expressed in most tumors and
contributes to increased glucose consumption and to in vivo tumor 18 F-FDG PET signaling. …

10.7554/eLife.47178.001 GPIHBP1, a GPI-anchored protein of capillary endothelial cells,
binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary …

Metabolites and metabolic co-factors can shape the innate immune response, though the
pathways by which these molecules adjust inflammation remain incompletely understood. …

OBJECTIVE: In this systematic review, we aim to synthesize the evidence on transitional
care interventions (TCIs) to improve the quality of life (QoL) for adolescents and young adults …

Background: A continued technical challenge for surgeons performing bone–patellar tendon–bone
anterior cruciate ligament (ACL) reconstruction with endoscopic techniques is graft-…