Background Heart failure can result from a variety of causes, including ischemic, hypertensive,
toxic, and inflammatory heart disease. However, the cellular mechanisms responsible for …

Apoptosis has been shown to contribute to loss of cardiomyocytes in cardiomyopathy,
progressive decline in left ventricular function, and congestive heart failure. Because the …

Although apoptosis is a well-recognized phenomenon in chronic atherosclerotic disease, its
role in sudden coronary death, in particular, acute plaque rupture is unknown. Culprit …

Oxidized low-density lipoprotein (ox-LDL) induces apoptosis in endothelial cells. However,
steps leading to ox-LDL–induced apoptosis remain unclear. We examined the role of ox-LDL …

Progressive inflammation in atherosclerotic plaques is associated with increasing risk of
plaque rupture. Molecular imaging of activated macrophages with 2-deoxy-2-[ 18 F]fluoro-D-…

Apoptosis or programmed cell death is an evolutionarily conserved process of cell death,
wherein cells die without provoking significant inflammatory response. There is convincing …

Background : Macrophages and fibroblasts are 2 major cell types involved in healing after
myocardial infarction (MI), contributing to myocardial remodeling and fibrosis. Post-MI fibrosis …

Ischemic insult to the myocardium is associated with cardiomyocyte apoptosis. Because
apoptotic cell death is characterized by phosphatidylserine externalization on cell membrane …

Background : Despite extensive evidence demonstrating the beneficial effects of statins on
clinical outcomes, the mechanisms underlying these effects remain elusive. Objectives : This …

Objectives : The aim of this study was to test the hypothesis that chronic mitochondrial
energy deficiency causes dilated cardiomyopathy, we characterized the hearts of age-matched …