Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen
receptor (ER)–positive breast tumors, and selective phosphatidylinositol 3-kinase α (PI3Kα) …

Both abundant epidermal growth factor receptor (EGFR or ErbB1) and high activity of the
phosphatidylinositol 3-kinase (PI3K)–Akt pathway are common and therapeutically targeted in …

1,4,7,10-Tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA) is one of the
preeminent carriers of metal-based radiopharmaceutics and imaging contrast agents. This …

Over the past several decades, radionuclides have matured from largely esoteric and
experimental technologies to indispensible components of medical diagnostics. Driving this …

The synthesis, characterization, in vitro imaging, and cytotoxic properties of a new folate
conjugate of rhenium(I) are reported. The conjugate [FA‐PEG‐BQAV‐Re(CO) 3 ] + (γ‐4) was …

We evaluated the ability of the PET imaging agent 89 Zr-trastuzumab to delineate HER2-positive
gastric cancer and to monitor the pharmacodynamic effects of the epidermal growth …

IFNγ is an attractive target for imaging active antitumor immunity due to its function in the T-cell
signaling axis. Here, we test an IFNγ immuno-PET (immunoPET) probe for its capacity to …

Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid
clearance from nontumor tissues. Here, we demonstrate that positron emission tomography (…

Liposomes are attractive vehicles for the controlled release of drugs and cytotoxins and have
a long-standing history in medical research and clinical practice. In addition to established …

Despite their considerable advantages, many circulating biomarkers have well-documented
limitations. One prominent shortcoming in oncology is a high frequency of false-positive …