Novel series of 111In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human …
…, GL Sieckman, DL Hayes, NK Owen… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Gastrin-releasing peptide (GRP) receptors have been shown to be expressed with high
densities on several types of cancer cells including prostate, breast, small cell lung, and …
densities on several types of cancer cells including prostate, breast, small cell lung, and …
Evaluation of an 111In-DOTA–rhenium cyclized α-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties
The aim of this study was to examine the effect of rhenium-mediated peptide cyclization on
melanoma targeting, biodistribution, and clearance kinetics of the α-melanocyte-stimulating …
melanoma targeting, biodistribution, and clearance kinetics of the α-melanocyte-stimulating …
Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN [7-14] NH2: an in vitro/in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 …
…, H Gali, GL Sieckman, DL Hayes, NK Owen… - Nuclear medicine and …, 2003 - Elsevier
Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin releasing peptide
(GRP) that binds to GRP receptors (GRPr) with high affinity and specificity. The GRPr is …
(GRP) that binds to GRP receptors (GRPr) with high affinity and specificity. The GRPr is …
Evaluation of the human melanoma targeting properties of radiolabeled α-melanocyte stimulating hormone peptide analogues
Y Miao, D Whitener, W Feng, NK Owen… - Bioconjugate …, 2003 - ACS Publications
The purpose of this study was to evaluate the human MC1 receptor-mediated melanoma
targeting properties of two metal cyclized α-MSH peptide analogues, 188 Re-(Arg 11 )CCMSH …
targeting properties of two metal cyclized α-MSH peptide analogues, 188 Re-(Arg 11 )CCMSH …
Radiochemical Investigations of Gastrin-releasing Peptide Receptor-specific [99mTc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, Tumor-bearing, Rodent Models: Syntheses, Radiolabeling, and …
CJ Smith, GL Sieckman, NK Owen, DL Hayes… - Cancer research, 2003 - AACR
Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide
(GRP) that binds to GRP receptors (GRPrs) with high affinity and specificity. The GRPr is …
(GRP) that binds to GRP receptors (GRPrs) with high affinity and specificity. The GRPr is …
In vivo evaluation of 188Re‐labeled alpha‐melanocyte stimulating hormone peptide analogs for melanoma therapy
Y Miao, NK Owen, D Whitener… - … journal of cancer, 2002 - Wiley Online Library
The purpose of our study was to optimize melanoma tumor uptake of 188 Re‐CCMSH and
reduce its nonspecific kidney retention. Nephrotoxicity is often a serious problem associated …
reduce its nonspecific kidney retention. Nephrotoxicity is often a serious problem associated …
Therapeutic efficacy of a 188Re-labeled α-melanocyte–stimulating hormone peptide analog in murine and human melanoma-bearing mouse models
Y Miao, NK Owen, DR Fisher, TJ Hoffman… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The purpose of this study was to examine the therapeutic efficacy of 188 Re-(Arg 11 )[Cys 3,4,10
,d-Phe 7 ]α-melanocyte–stimulating hormone 3–13 (CCMSH) in the B16/F1 murine …
,d-Phe 7 ]α-melanocyte–stimulating hormone 3–13 (CCMSH) in the B16/F1 murine …
Biodistribution of filamentous phage peptide libraries in mice
J Zou, MT Dickerson, NK Owen, LA Landon… - Molecular biology …, 2004 - Springer
In vivo phage display is a new approach to acquire peptide molecules that bind stably to a
given target. Phage peptide display libraries have been selected in mice and humans and …
given target. Phage peptide display libraries have been selected in mice and humans and …
Synthesis, Characterization, and Labeling with 99mTc/188Re of Peptide Conjugates Containing a Dithia-bisphosphine Chelating Agent
H Gali, TJ Hoffman, GL Sieckman, NK Owen… - Bioconjugate …, 2001 - ACS Publications
Radiolabeling of small receptor-avid peptides at specific predetermined chelation sites with
radioactive metals has been an effective approach for production of target-specific …
radioactive metals has been an effective approach for production of target-specific …
Modification of the Structure of a Metallopeptide: Synthesis and Biological Evaluation of 111In-Labeled DOTA-Conjugated Rhenium-Cyclized α-MSH Analogues
Rhenium-cyclized CCMSH analogues are novel melanoma-targeting metallopeptides with
high tumor uptake, long tumor retention, and low background in normal tissues, which make …
high tumor uptake, long tumor retention, and low background in normal tissues, which make …