Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate

N Saigal, R Pichika, B Easwaramoorthy… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Serotonin 5-HT 1A receptors have been implicated in disorders of the central nervous system
and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability …

Evaluation of serotonin 5‐HT1A receptors in rodent models using [18F]mefway PET

N Saigal, AK Bajwa, SS Faheem, RA Coleman… - Synapse, 2013 - Wiley Online Library
Introduction Serotonin 5‐HT 1A receptors have been investigated in various CNS disorders,
including epilepsy, mood disorders, and neurodegeneration. [ 18 F]Mefway (N‐{2‐[4‐(2′‐…

Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging

…, DJ Williamson, V Ferrari, N Saigal… - Journal of Nuclear …, 2013 - Soc Nuclear Med
We have investigated the opioid receptor (OR) agonist (20R)-4,5-α-epoxy-6-(2- 18 F-fluoroethoxy)-3-hydroxy-α,17-dimethyl-α-(2-phenyleth-1-yl)-6,14-ethenomorphinan-7-methanol
( 18 …

Comparative assessment of 18F‐Mefway as a serotonin 5‐HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans

…, ML Pan, SK Pandey, N Saigal… - Journal of …, 2016 - Wiley Online Library
We have developed 18 F‐trans‐Mefway ( 18 F‐Mefway) for positron emission tomography (PET)
imaging studies of serotonin 5‐HT 1A receptors which are implicated in various brain …

18F-Mefway: Efficacy as a PET imaging agent for serotonin 5-HT1A receptors

A Bajwa, A Hillmer, D Wooten, N Saigal, B Christian… - 2014 - Soc Nuclear Med
553 Objectives Serotonin 5-HT 1A receptors, implicated in CNS disorders, have been
studied with 18 F-trans-Mefway ( 18 F-Mefway) in rodent and nonhuman primate studies. …

Serotonin competition with the new 5-HT1A receptor PET radiotracer: 18F-mefway

N Saigal, R Pichika, B Easwaramoorthy, D Collins… - 2006 - Soc Nuclear Med
1151 Objectives: Changes in serotonin levels in the brain have proved difficult to measure
using PET radiotracers. Competition of endogenous serotonin (fenfluramine-induced …

18F-Mefway binding to serotonin 5HT1A receptors is reduced in transgenic mouse models of Alzheimer's disease

N Saigal, B Easwaramoorthy, M Nistor, D Do, E Head… - 2007 - Soc Nuclear Med
392 Objectives: Previous work in humans (Kepe, 2005) has shown a 27% hippocampus (HP)
decrease in serotonin 5HT1A receptors in Alzheimer’s disease (AD) using 18F-MPPF. In …

18F-Mefway microPET imaging in rat brains

…, E Sevrioukov, C Constantinescu, ML Pan, N Saigal… - 2011 - Soc Nuclear Med
1571 Objectives Serotonin 5HT1A receptors have been investigated in various CNS disorders,
including depression, epilepsy and Alzheimer’s disease. F-Mefway is a new PET imaging …

Measurement of brain and plasma metabolites of 18F-Nifene

…, R Pichika, C Constantinescu, N Saigal… - 2008 - Soc Nuclear Med
566 Objectives: 2-[ 18 F]Fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine, 18F-Nifene, is a new
tracer for the α4β2 nicotinic acetylcholine receptors, with faster binding profile in monkey …

Radiotracers for a multi‐target approach to the diagnosis of Alzheimer's disease

…, D Collins, I Chen, CS Wang, N Saigal… - Journal of Labelled …, 2007 - Wiley Online Library
Abstract Development of β‐amyloid plaques and neurofibrillary tangles is the hallmark of
Alzheimer's disease (AD) and progressively affects the overall functioning of the brain. …