Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

DR Owen, N Narayan, L Wells… - Journal of Cerebral …, 2017 - journals.sagepub.com
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker
of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid …

[HTML][HTML] The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1'human macrophages

N Narayan, H Mandhair, E Smyth, SG Dakin… - PloS one, 2017 - journals.plos.org
The translocator protein (TSPO) is a mitochondrial membrane protein, of as yet uncertain
function. Its purported high expression on activated macrophages, has lent utility to TSPO …

Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus

N Narayan, DR Owen, H Mandhair… - Journal of Nuclear …, 2018 - Soc Nuclear Med
PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific
means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression …

Advances in positron emission tomography for the imaging of rheumatoid arthritis

N Narayan, DR Owen, PC Taylor - Rheumatology, 2017 - academic.oup.com
Imaging techniques, such as US, are well recognized as important tools to aid early diagnosis
and assess response to treatment in RA. PET offers a means of imaging the inflammatory …

BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: baseline multi-centre audit in the UK

…, RL Batten, R Garner, J Little, N Narayan… - …, 2021 - academic.oup.com
Objectives To assess the baseline care provided to patients with SLE attending UK Rheumatology
units, audited against standards derived from the recently published BSR guideline …

The value of ultrasound-defined tenosynovitis and synovitis in the prediction of persistent arthritis

…, E Justice, E Derrett-Smith, N Amft, N Narayan… - …, 2023 - academic.oup.com
Objectives The value of US-defined tenosynovitis in predicting the persistence of inflammatory
arthritis is not well described. In particular, the predictive utility of US-defined tenosynovitis …

Estimation of the burden of shielding among a cross-section of patients attending rheumatology clinics with SLE—data from the BSR audit of systemic lupus …

…, RL Batten, R Garner, J Little, N Narayan… - …, 2021 - academic.oup.com
Objectives We aimed to estimate what proportion of people with SLE attending UK
rheumatology clinics would be categorized as being at high risk from coronavirus disease 2019 (…

[HTML][HTML] Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis

N Narayan, S Rigby, F Carlucci - Clinical rheumatology, 2017 - Springer
Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often
chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune …

Secondary syphilis mimicking giant cell arteritis

N Narayan, P Bennett, C Chan… - JCR: Journal of Clinical …, 2020 - journals.lww.com
To the Editor: Giant cell arteritis (GCA) is the most common form of vasculitis in those older
than 50 years and is widely considered in the differential diagnosis of headache in the elderly…

[PDF][PDF] 47. Activated PI3 kinase delta syndrome: a rare cause of inflammatory disease

N Narayan, P Hewins, P Lane… - … Advances in Practice, 2018 - academic.oup.com
Discussion: Subglottic stenosis is an uncommon life-threatening manifestation of
granulomatosis with polyangiitis (GPA) and can occur both at diagnosis and subsequent to it. It …