Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans
DR Owen, N Narayan, L Wells… - Journal of Cerebral …, 2017 - journals.sagepub.com
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker
of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid …
of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid …
[HTML][HTML] The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1'human macrophages
The translocator protein (TSPO) is a mitochondrial membrane protein, of as yet uncertain
function. Its purported high expression on activated macrophages, has lent utility to TSPO …
function. Its purported high expression on activated macrophages, has lent utility to TSPO …
Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus
N Narayan, DR Owen, H Mandhair… - Journal of Nuclear …, 2018 - Soc Nuclear Med
PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific
means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression …
means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression …
Advances in positron emission tomography for the imaging of rheumatoid arthritis
N Narayan, DR Owen, PC Taylor - Rheumatology, 2017 - academic.oup.com
Imaging techniques, such as US, are well recognized as important tools to aid early diagnosis
and assess response to treatment in RA. PET offers a means of imaging the inflammatory …
and assess response to treatment in RA. PET offers a means of imaging the inflammatory …
BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: baseline multi-centre audit in the UK
…, RL Batten, R Garner, J Little, N Narayan… - …, 2021 - academic.oup.com
Objectives To assess the baseline care provided to patients with SLE attending UK Rheumatology
units, audited against standards derived from the recently published BSR guideline …
units, audited against standards derived from the recently published BSR guideline …
The value of ultrasound-defined tenosynovitis and synovitis in the prediction of persistent arthritis
…, E Justice, E Derrett-Smith, N Amft, N Narayan… - …, 2023 - academic.oup.com
Objectives The value of US-defined tenosynovitis in predicting the persistence of inflammatory
arthritis is not well described. In particular, the predictive utility of US-defined tenosynovitis …
arthritis is not well described. In particular, the predictive utility of US-defined tenosynovitis …
Estimation of the burden of shielding among a cross-section of patients attending rheumatology clinics with SLE—data from the BSR audit of systemic lupus …
…, RL Batten, R Garner, J Little, N Narayan… - …, 2021 - academic.oup.com
Objectives We aimed to estimate what proportion of people with SLE attending UK
rheumatology clinics would be categorized as being at high risk from coronavirus disease 2019 (…
rheumatology clinics would be categorized as being at high risk from coronavirus disease 2019 (…
[HTML][HTML] Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis
N Narayan, S Rigby, F Carlucci - Clinical rheumatology, 2017 - Springer
Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often
chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune …
chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune …
Secondary syphilis mimicking giant cell arteritis
N Narayan, P Bennett, C Chan… - JCR: Journal of Clinical …, 2020 - journals.lww.com
To the Editor: Giant cell arteritis (GCA) is the most common form of vasculitis in those older
than 50 years and is widely considered in the differential diagnosis of headache in the elderly…
than 50 years and is widely considered in the differential diagnosis of headache in the elderly…
[PDF][PDF] 47. Activated PI3 kinase delta syndrome: a rare cause of inflammatory disease
N Narayan, P Hewins, P Lane… - … Advances in Practice, 2018 - academic.oup.com
Discussion: Subglottic stenosis is an uncommon life-threatening manifestation of
granulomatosis with polyangiitis (GPA) and can occur both at diagnosis and subsequent to it. It …
granulomatosis with polyangiitis (GPA) and can occur both at diagnosis and subsequent to it. It …