Complement in renal transplantation: The road to translation

NM Jager, F Poppelaars, MR Daha, MA Seelen - Molecular Immunology, 2017 - Elsevier
Renal transplantation is the treatment of choice for patients with end-stage renal disease.
The vital role of the complement system in renal transplantation is widely recognized. This …

Assessment of estrogen receptor expression in epithelial ovarian cancer patients using 16α-18F-fluoro-17β-estradiol PET/CT

…, EFJ de Vries, HJG Arts, NM Jager… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The estrogen receptor α (ERα) is expressed in approximately 70% of ovarian cancer tumors.
PET of tumor ERα expression with the tracer 16α- 18 F-fluoro-17β-estradiol ( 18 F-FES) may …

[HTML][HTML] Complement therapeutics in the multi-organ donor: do or don't?

JE van Zanden, NM Jager, MR Daha… - Frontiers in …, 2019 - frontiersin.org
Over the last decade, striking progress has been made in the field of organ transplantation,
such as better surgical expertise and preservation techniques. Therefore, organ …

C1-inhibitor treatment decreases renal injury in an established brain-dead rat model

F Poppelaars, NM Jager, J Kotimaa… - …, 2018 - journals.lww.com
Background Kidneys derived from brain-dead (BD) donors have lower graft survival rates
compared with kidneys from living donors. Complement activation plays an important role in …

[HTML][HTML] Complement is activated during normothermic machine perfusion of porcine and human discarded kidneys

NM Jager, LH Venema, AS Arykbaeva… - Frontiers in …, 2022 - frontiersin.org
Background The gap between demand and supply of kidneys for transplantation necessitates
the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is …

[HTML][HTML] Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in …

…, S Yang, MA Hu, JS Jainandunsing, NM Jager… - International Journal of …, 2024 - mdpi.com
Volatile anesthetics have been shown in different studies to reduce ischemia reperfusion
injury (IRI). Ex vivo lung perfusion (EVLP) facilitates graft evaluation, extends preservation time …

[HTML][HTML] Blocking complement factor B activation reduces renal injury and inflammation in a rat brain death model

NM Jager, JE Van Zanden, M Subías… - Frontiers in …, 2019 - frontiersin.org
Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead
organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic …

[HTML][HTML] Brain death-induced lung injury is complement dependent, with a primary role for the classical/lectin pathway

JE van Zanden, NM Jager, MA Seelen… - American Journal of …, 2021 - Elsevier
In brain-dead donors immunological activation occurs, which deteriorates donor lung quality.
Whether the complement system is activated and which pathways are herein involved, …

[PDF][PDF] Complement in transplantation: the road to translation

NM Jager, F Poppelaars, MR Daha… - … modulation to improve …, 2021 - research.rug.nl
Renal transplantation is the treatment of choice for patients with endrstage renal disease.
The vital role of the complement system in renal transplantation is widely recognized. This …

[PDF][PDF] Brain death-induced lung injury is complement dependent with a primary role for the classical/lectin pathway

NM Jager, JE van Zanden, MA Seelen… - … to improve donor …, 2021 - research.rug.nl
In brainrdead donors immunological activation occurs, which deteriorates donor lung quality.
Whether the complement system is activated and which pathways are herein involved, …