Background— Recent data highlight a vital link between well-performed cardiopulmonary
resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually …

β-Catenin is a signaling molecule that promotes cell proliferation by the induction of gene
transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) …

Myofibroblasts are modified fibroblasts characterized by the presence of a well-developed
contractile apparatus and the formation of robust actin stress fibers. These mechanically …

10.7554/eLife.36865.001 Pdgfra-expressing (Pdgfra+) cells have been implicated as
progenitors in many mesenchymal tissues. To determine lineage potential, we generated Pdgfra …

Transforming growth factor-β (TGF-β) is a cytokine implicated in wound healing and in the
pathogenesis of pulmonary fibrosis. TGF-β stimulates myofibroblast differentiation …

Myofibroblast differentiation induced by transforming growth factor-β (TGF-β) and characterized
by de novo expression of smooth muscle (SM)-specific proteins is a key process in …

Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis (IPF)
activity or treatment response remains an unmet clinical need. Herein, we determined …

Myofibroblasts have increased expression of contractile proteins and display augmented
contractility. It is not known if the augmented contractile gene expression characterizing the …

Extracellular ATP stimulates proliferation of vascular smooth muscle cells (VSMC) through
activation of G protein-coupled P2Y purinergic receptors. We have previously shown that ATP …

Rationale and Objectives: The purpose of this review is to acquaint the reader with recent
advances in ultrashort echo time (UTE) magnetic resonance imaging (MRI) of the lung and its …