PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
…, B Shen, E Chang, C Pohling, N Arksey… - Science translational …, 2015 - science.org
Cancer cells reprogram their metabolism to meet increased biosynthetic demands, commensurate
with elevated rates of replication. Pyruvate kinase M2 (PKM2) catalyzes the final and …
with elevated rates of replication. Pyruvate kinase M2 (PKM2) catalyzes the final and …
PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2, 5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl) acetamide
…, Z Ding, H Liu, D Bodapati, N Arksey… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Herein we aimed to evaluate the utility of N-(2,5-dimethoxybenzyl)-2- 18 F-fluoro-N-(2-phenoxyphenyl)acetamide
( 18 F-PBR06) for detecting alterations in translocator protein (TSPO) (…
( 18 F-PBR06) for detecting alterations in translocator protein (TSPO) (…
[HTML][HTML] Further validation to support clinical translation of [18F]FTC-146 for imaging sigma-1 receptors
…, C Lau, S Chen, M Palner, Z Miao, NC Arksey… - EJNMMI research, 2015 - Springer
Background This study aims to further evaluate the specificity and selectivity of [ 18 F]FTC-146
and obtain additional data to support its clinical translation. Methods The binding of [ 19 F]…
and obtain additional data to support its clinical translation. Methods The binding of [ 19 F]…
The Relationship Between Serial [18 F]PBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice
Purpose Using [ 18 F]PBR06 positron emission tomography (PET) to characterize the time
course of stroke-associated neuroinflammation (SAN) in mice, to evaluate whether brain …
course of stroke-associated neuroinflammation (SAN) in mice, to evaluate whether brain …
Synthesis and evaluation of the novel 2-[18F] fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT1 receptors
N Arksey, T Hadizad, B Ismail, M Hachem… - Bioorganic & Medicinal …, 2014 - Elsevier
The 2-[ 18 F]fluoro-3-pent-4-yn-1-yloxypyridine ([ 18 F]FPyKYNE) analog of the potent non-peptide
angiotensin II type 1 receptor (AT 1 R) blocker losartan was produced via click …
angiotensin II type 1 receptor (AT 1 R) blocker losartan was produced via click …
Characterization of 18F-FPyKYNE-Losartan for imaging AT1 receptors
…, M Tiberi, B Ismail, CR Hunter, N Arksey… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Most physiologic effects of the renin angiotensin system (RAS) are mediated via the angiotensin
(Ang) type 1 receptor (AT 1 R). The 18 F-FPyKYNE derivative of the clinically used AT 1 …
(Ang) type 1 receptor (AT 1 R). The 18 F-FPyKYNE derivative of the clinically used AT 1 …
Validation of 64Cu-DOTA-rituximab injection preparation under good manufacturing practices: a PET tracer for imaging of B-cell non-Hodgkin lymphoma.
A Natarajan, N Arksey, A Iagaru, FT Chin… - Molecular …, 2015 - europepmc.org
Manufacturing of 64Cu-1, 4, 7, 10-tetraazacyclododecane-N, N', N'', N'''-tetraacetic acid (DOTA)-rituximab
injection under good manufacturing practices (GMP) was validated for imaging …
injection under good manufacturing practices (GMP) was validated for imaging …
[HTML][HTML] FLT-PET-CT for the detection of disease recurrence after stereotactic ablative radiotherapy or hyperfractionation for thoracic malignancy: A prospective pilot …
Differentiating local recurrence from post-treatment changes on PET scans following stereotactic
ablative radiotherapy (SABR) or hyperfractionation for lung tumors is challenging. We …
ablative radiotherapy (SABR) or hyperfractionation for lung tumors is challenging. We …
[BOOK][B] Synthesis and Preliminary Evaluation of an F-18 Labeled Fluoropyridine Losartan Analog as a Novel PET Tracer for Imaging AT1 Receptors
N Arksey - 2012 - search.proquest.com
Several cardiac diseases, including hypertrophy, cardiomyopathy, and myocardial infarction,
result in the upregulation of cardiac angiotensin II type-1 receptors (AT 1 R). Imaging the AT …
result in the upregulation of cardiac angiotensin II type-1 receptors (AT 1 R). Imaging the AT …
Synthesis of a novel F-18 labeled fluoropyridine analog of losartan for PET imaging of AT1 receptors
N Arksey, A Valdivia, J Collins, T Hadizad… - 2011 - Soc Nuclear Med
1490 Objectives The aim of this study was to synthesize an F-18 labeled analog of losartan
for PET imaging of AT1 receptors via ‘click’ chemistry with 2-[ 18 F]fluoro-3-pent-4-yn-1-…
for PET imaging of AT1 receptors via ‘click’ chemistry with 2-[ 18 F]fluoro-3-pent-4-yn-1-…