User profiles for Narges Tafreshi
Narges TafreshiCellinfinity Bio Verified email at cellinfinitybio.com Cited by 1365 |
Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases
Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes
the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer …
the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer …
[HTML][HTML] Development of targeted alpha particle therapy for solid tumors
NK Tafreshi, ML Doligalski, CJ Tichacek, DN Pandya… - Molecules, 2019 - mdpi.com
Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles
(cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or small …
(cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or small …
[HTML][HTML] Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …
Molecular and functional imaging of breast cancer
NK Tafreshi, V Kumar, DL Morse… - Cancer …, 2010 - journals.sagepub.com
Background Significant efforts have been directed toward developing and enhancing imaging
methods for the early detection, diagnosis, and characterization of small breast tumors. …
methods for the early detection, diagnosis, and characterization of small breast tumors. …
Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia
NK Tafreshi, MC Lloyd, JB Proemsey, MM Bui… - Molecular imaging and …, 2016 - Springer
Purpose Hypoxia is commonly observed in regions of primary tumors and metastases, and
is associated with resistance to treatment, more aggressive tumor phenotypes and poor …
is associated with resistance to treatment, more aggressive tumor phenotypes and poor …
Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes
NK Tafreshi, MM Bui, K Bishop, MC Lloyd… - Clinical Cancer …, 2012 - AACR
Purpose: To develop targeted molecular imaging probes for the noninvasive detection of
breast cancer lymph node metastasis. Experimental Design: Six cell surface or secreted …
breast cancer lymph node metastasis. Experimental Design: Six cell surface or secreted …
[HTML][HTML] The influence of insertion of a critical residue (Arg356) in structure and bioluminescence spectra of firefly luciferase
The firefly bioluminescence reaction, which uses luciferin, Mg-ATP, and molecular oxygen
to yield an electronically excited oxyluciferin, is carried out by luciferase and visible light is …
to yield an electronically excited oxyluciferin, is carried out by luciferase and visible light is …
Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms
NK Tafreshi, DN Pandya, CJ Tichacek… - European journal of …, 2021 - Springer
Purpose There is significant interest in the development of targeted alpha-particle therapies
(TATs) for treatment of solid tumors. The metal chelator-peptide conjugate, DOTA-TATE, …
(TATs) for treatment of solid tumors. The metal chelator-peptide conjugate, DOTA-TATE, …
Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand
NM Barkey, NK Tafreshi, JS Josan… - Journal of medicinal …, 2011 - ACS Publications
The incidence of malignant melanoma is rising faster than that of any other cancer in the
United States. Because of its high expression on the surface of melanomas, MC1R has been …
United States. Because of its high expression on the surface of melanomas, MC1R has been …
Melanocortin 1 receptor–targeted α-particle therapy for metastatic uveal melanoma
NK Tafreshi, CJ Tichacek, DN Pandya… - Journal of Nuclear …, 2019 - Soc Nuclear Med
New effective therapies are greatly needed for metastatic uveal melanoma, which has a
very poor prognosis with a median survival of less than 1 y. The melanocortin 1 receptor (MC1R) …
very poor prognosis with a median survival of less than 1 y. The melanocortin 1 receptor (MC1R) …