DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1
…, K Hagihara, J Yamaguchi, C Ishii, N Harada… - Clinical Cancer …, 2016 - AACR
Purpose: An anti-HER2 antibody–drug conjugate with a novel topoisomerase I inhibitor, DS-8201a,
was generated as a new antitumor drug candidate, and its preclinical pharmacologic …
was generated as a new antitumor drug candidate, and its preclinical pharmacologic …
Preparation of asymmetric urea derivatives that target prostate-specific membrane antigen for SPECT imaging
N Harada, H Kimura, M Ono, H Saji - Journal of Medicinal …, 2013 - ACS Publications
Prostate-specific membrane antigen (PSMA) has been identified as a diagnostic and
therapeutic target for prostate cancer. (S)-2-[3-[(R)-1-Carboxy-2-mercaptoethyl]ureido-pentanedioic …
therapeutic target for prostate cancer. (S)-2-[3-[(R)-1-Carboxy-2-mercaptoethyl]ureido-pentanedioic …
Synthesis and biologic evaluation of novel 18F-labeled probes targeting prostate-specific membrane antigen for PET of prostate cancer
N Harada, H Kimura, S Onoe, H Watanabe… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a membrane protein highly expressed on
prostate cancer cells and a potential imaging target for diagnosis. F-DCFPyL has been recently …
prostate cancer cells and a potential imaging target for diagnosis. F-DCFPyL has been recently …
CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining
DR Iyer, N Harada, C Clairmont… - Proceedings of the …, 2022 - National Acad Sciences
The 53BP1-RIF1 pathway restricts the resection of DNA double-strand breaks (DSBs) and
promotes blunt end-ligation by non-homologous end joining (NHEJ) repair. The Shieldin …
promotes blunt end-ligation by non-homologous end joining (NHEJ) repair. The Shieldin …
Detection and localization of interleukin-8 mRNA and protein in human placenta and decidual tissues
…, S Sakakura, H Umekage, N Harada… - Journal of Reproductive …, 1994 - Elsevier
It has been reported that interleukin-8 (IL-8) is secreted from the placental and decidual tissues
and that IL-8 levels in the amniotic fluids are significantly elevated by chorioamnionitis or …
and that IL-8 levels in the amniotic fluids are significantly elevated by chorioamnionitis or …
[HTML][HTML] Multiple metastatic gestational trophoblastic disease after a twin pregnancy with complete hydatidiform mole and coexisting fetus, following assisted …
I Nobuhara, N Harada, N Haruta, Y Higashiura… - Taiwanese Journal of …, 2018 - Elsevier
Objective Twin pregnancy with complete hydatidiform mole and coexisting fetus (CHMCF) is
rare and associated with severe complications during pregnancy and subsequent …
rare and associated with severe complications during pregnancy and subsequent …
Interleukin-8 production by CD16− CD56bright natural killer cells in the human early pregnancy decidua
…, M Enomoto, H Umekage, N Harada… - Biochemical and …, 1994 - Elsevier
Decidual CD16 − CD56 bright natural killer (NK) cells were sorted from the decidual
mononuclear cells (MNC) at the early pregnancy using a fluorescence activated cell sorter. The …
mononuclear cells (MNC) at the early pregnancy using a fluorescence activated cell sorter. The …
Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of 99mTc-Hydroxamamide Complexes
…, K Matsumura, M Yoshimura, N Harada… - Molecular …, 2014 - ACS Publications
Deposition of amyloid aggregates has been regarded as an early stage of amyloidosis
progression. An imaging probe that can image amyloid aggregates enables the early diagnosis …
progression. An imaging probe that can image amyloid aggregates enables the early diagnosis …
Interleukin 4 (IL-4) Blocks the IL-2-Induced Increase in Natural Killer Activity and DNA Synthesis of Decidual CD16− CD56brightNK Cells by Inhibiting Expression of …
…, N Narita, M Enomoto, S Sakakura, N Harada… - Cellular …, 1996 - Elsevier
The natural killer (NK) activity and DNA synthesis of decidual CD16 − CD56 bright NK cells
were markedly elevated by treatment with interleukin 2 (IL-2). IL-4 did not affect NK activity or …
were markedly elevated by treatment with interleukin 2 (IL-2). IL-4 did not affect NK activity or …
A case of uterine torsion concurrent with a ruptured ovarian endometrial cyst
A Hashimoto, J Takahama, N Harada, S Maeda… - Abdominal …, 2016 - Springer
The patient was a 54-year-old female presented with severe abdominal swelling and
intermittent pain. On emergent CT, massive ascites with thickened peritoneum and intra-pelvic …
intermittent pain. On emergent CT, massive ascites with thickened peritoneum and intra-pelvic …