This was a first-in-human study of the PET radiotracer 11 C-LSN3172176 for the muscarinic
acetylcholine receptor subtype M1. The objectives of the study were to determine the …

Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important
role in the progression of Alzheimer disease. Animal studies suggest that one strategy …

We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine
(O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as …

Background Previous studies found that [ 18 F]LSN3316612 was a promising positron
emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and …

… At the time this work was conducted, Nancy Kant and Cynthia Jesudason were employees
of Eli Lilly. No other potential conflict of interest relevant to this article was reported. …

… Nancy gives to Kant's response is fully justified. Does Kant actually say this? Not as such.
At first glance, Nancy's answer seems so far off target that, even if only to read over …

… Kant repeatedly uses to discuss the communicability of the feeling of pleasure that is integral
to the aesthetic judgment alongside Nancy’s … in the English translation of Nancy’s essay it is …

Objectives: This is a first-in-human study of the PET radiotracer 11 C-LSN3172176 for the
muscarinic acetylcholine receptor subtype 1 (M1). The objectives of this study were to …

Purpose Positron emission tomography (PET) is a widely used imaging technique with many
biomedical and drug development applications. The implementation of this technology …

275 Objectives: The M1 muscarinic acetylcholine receptor (mAChR) is implicated in a
number of neurological and psychiatric diseases, and is a target for drug development for …