The neonatal Fc receptor, FcRn mediates an endocytic salvage pathway that prevents
degradation of IgG, thus contributing to the homeostasis of circulating IgG. Based on the low …

Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor that may
play a pathophysiologic role in anxiety and drug abuse and is a potential therapeutic target in …

[ 11 C]NOP-1A is a novel high-affinity PET ligand for imaging nociceptin/orphanin FQ
peptide (NOP) receptors. Here, we report reproducibility and reliability measures of binding …

The recent production of a series of monoclonal estrophilin (estrogen receptor) antibodies
recognizing estrogen receptor derived from a wide variety of animals and target tissues …

Calcitonin gene‐related peptide (CGRP) is a neuropeptide that is associated with a subset
of primary afferent fibers and appears to have a role in nociception. The purpose of the …

Calcitonin gene‐related peptide (CGRP) is a neuropeptide that has been implicated in the
transmission and modulation of primary afferent nociceptive stimuli. In this study, we describe …

Our laboratory developed (S)-3-(2′-fluoro-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide
( 11 C-NOP-1A), a new radioligand …

Intraparenchymal postnatal development of the CNS vasculature proceeds by a process of
vascular ‘budding’ or ‘sprouting’ from existing endothelial cells and elongation of these …

A sensitive method has been developed for the identification and assessment of phosphorothioate
oligonucleotide accumulation in dosed animal tissues using an in situ hybridization …

Purpose Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1
and mGluR5) were evaluated as positron emission tomography (PET) radioligands for …