Widespread changes in dendritic and axonal morphology in Mecp2‐mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks
PV Belichenko, EE Wright… - Journal of …, 2009 - Wiley Online Library
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X‐linked
gene MECP2. Girls with RTT show dramatic changes in brain function, but relatively few …
gene MECP2. Girls with RTT show dramatic changes in brain function, but relatively few …
The “Down syndrome critical region” is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down …
NP Belichenko, PV Belichenko… - Journal of …, 2009 - Soc Neuroscience
Down syndrome (DS) can be modeled in mice segmentally trisomic for mouse chromosome
16. Ts65Dn and Ts1Cje mouse models have been used to study DS neurobiological …
16. Ts65Dn and Ts1Cje mouse models have been used to study DS neurobiological …
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease
DA Simmons, NP Belichenko, T Yang… - Journal of …, 2013 - Soc Neuroscience
Loss of neurotrophic support in the striatum caused by reduced brain-derived neurotrophic
factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF …
factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF …
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome
NP Belichenko, PV Belichenko, HH Li… - Journal of …, 2008 - Wiley Online Library
Rett syndrome (RTT) is caused by mutations in the X‐linked gene MECP2. While patients
with RTT show widespread changes in brain function, relatively few studies document …
with RTT show widespread changes in brain function, relatively few studies document …
Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
…, JK Ryu, L Li, SN Farina, NP Belichenko… - Journal of Experimental …, 2017 - rupress.org
Recent genetic evidence supports a link between microglia and the complement system in
Alzheimer’s disease (AD). In this study, we uncovered a novel role for the microglial …
Alzheimer’s disease (AD). In this study, we uncovered a novel role for the microglial …
[HTML][HTML] A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage …
DA Simmons, JK Knowles, NP Belichenko, G Banerjee… - PloS one, 2014 - journals.plos.org
Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive
deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant …
deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant …
Small molecule p75 NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in …
…, LN Quach, NP Belichenko… - Journal of …, 2014 - content.iospress.com
The p75 neurotrophin receptor (p75 NTR) is involved in degenerative mechanisms related to
Alzheimer's disease (AD). In addition, p75 NTR levels are increased in AD and the receptor …
Alzheimer's disease (AD). In addition, p75 NTR levels are increased in AD and the receptor …
[HTML][HTML] [18F] GE-180 PET detects reduced microglia activation after LM11A-31 therapy in a mouse model of Alzheimer's disease
ML James, NP Belichenko, AJ Shuhendler… - Theranostics, 2017 - ncbi.nlm.nih.gov
Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging
of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo. Here …
of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo. Here …
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation
NP Belichenko, PV Belichenko, WC Mobley - Neurobiology of disease, 2009 - Elsevier
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in
the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have …
the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have …
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice
DA Simmons, NP Belichenko, EC Ford… - Human molecular …, 2016 - academic.oup.com
Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical
role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 …
role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 …