Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Drug addiction is a chronically relapsing disorder that has been characterized by (1) compulsion
to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence of a …

The loss of control over drug intake that occurs in addiction was initially believed to result from
disruption of subcortical reward circuits. However, imaging studies in addictive behaviours …

… Nora Volkow designed the study, analysed PET scan data, and wrote the paper. Jean
Logan and Christopher Wong analysed the PET scan data and were responsible for data …

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role
in addiction is much less clear. This review focuses on studies that used PET to characterize …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-addicted
subjects that provide new insights into the mechanisms underlying addiction. …

Understanding the changes in the brain which occur in the transition from normal to addictive
behavior has major implications in public health. Here we postulate that while reward …

Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of
movement, cognition, motivation and reward. This leads to an increase in extracellular dopamine; …

Advances in neuroscience identified addiction as a chronic brain disease with strong genetic,
neurodevelopmental, and sociocultural components. We here discuss the circuit- and cell-…

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …